脯氨酸基膦配体用于 Staudinger 连接反应。

A proline-based phosphine template for Staudinger ligation.

机构信息

Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.

出版信息

Org Lett. 2012 Sep 7;14(17):4694-7. doi: 10.1021/ol3022484. Epub 2012 Aug 27.

Abstract

A proline-based phosphine template enabling a rapid Staudinger ligation of azide-containing substrates under mild conditions is reported. This reaction has a second-order rate constant of 1.12 M(-1) s(-1). It is expected that the proline-based Staudinger ligation strategy will be a useful method for bioconjugation and proline based peptide coupling.

摘要

本文报道了一种基于脯氨酸的膦模板，可在温和条件下实现含叠氮化物底物的快速 Staudinger 连接。该反应的二级速率常数为 1.12 M(-1) s(-1)。预计基于脯氨酸的 Staudinger 连接策略将成为生物缀合和脯氨酸基肽偶联的有用方法。