Department of Laboratory Medicine, Bloodless Center, Soonchunhyang University Hospital, Seoul, Korea.
Transfusion. 2013 May;53(5):948-54. doi: 10.1111/j.1537-2995.2012.03859.x. Epub 2012 Aug 23.
The Soonchunhyang University Hospital Bloodless Center was established in 2000, and more than 2000 bloodless surgeries has been performed there since. This study was carried out to analyze the characteristics of patients who underwent bloodless surgery and the influences of postoperative lowest hemoglobin level (H(blow)) along with the lowest postoperative Hb/preoperative Hb ratio (H(blow/pre)) on successful completion of bloodless surgery.
A total of 1407 patients were included. Patients were divided according to H(blow) into not more than 7 and more than 7 g/dL groups and compared regarding use of transfusion alternatives, coexisting risk factors, and mortality rate. They were also grouped as H(blow/pre) of not more than 0.5 or more than 0.5, and mortalities were compared between them.
Jehovah's Witnesses comprised 1323 (94.0%) of the total population. The frequency of simultaneous use of erythropoietin and iron was significantly higher in H(blow) of not more than 7 group than in more than 7 g/dL group, as was the use of hemostatics. Among risk factors urging transfusion, the frequencies of cardiovascular disease and cerebrovascular accident were higher in H(blow) of not more than 7 than in the more than 7 g/dL group. Mortality rates in H(blow) of not more than 7 g/dL and H(blow/pre) of not more than 0.5 groups were significantly higher than those in H(blow) of more than 7 g/dL and H(blow/pre) of more than 0.5 groups, respectively.
We have provided an effective bloodless surgery program for the past 10 years. A prospective multicenter study with other bloodless centers in Korea concerning mortality rates, actual operative blood loss, and postoperative complications in high-risk group of patients would be needed to establish evidence-based guidelines for bloodless surgery.
顺天乡大学医院无血中心成立于 2000 年,自那时以来已经完成了 2000 多例无血手术。本研究旨在分析接受无血手术患者的特点,以及术后最低血红蛋白水平(H(blow))和最低术后 Hb/术前 Hb 比值(H(blow/pre))对无血手术成功完成的影响。
共纳入 1407 例患者。根据 H(blow)将患者分为不超过 7 克/分升和超过 7 克/分升两组,并比较两组的输血替代物使用情况、并存危险因素和死亡率。还将他们分为 H(blow/pre)不超过 0.5 和超过 0.5,比较两组之间的死亡率。
1407 例患者中,1323 例(94.0%)为耶和华见证会成员。H(blow)不超过 7 克/分升组的促红细胞生成素和铁同时使用频率明显高于 H(blow)超过 7 克/分升组,止血剂的使用频率也高于后者。在需要输血的危险因素中,H(blow)不超过 7 克/分升组的心血管疾病和脑血管意外的发生率高于 H(blow)超过 7 克/分升组。H(blow)不超过 7 克/分升和 H(blow/pre)不超过 0.5 组的死亡率明显高于 H(blow)超过 7 克/分升和 H(blow/pre)超过 0.5 组。
我们在过去 10 年中为无血手术提供了有效的方案。需要进行前瞻性多中心研究,联合韩国其他无血中心,研究高风险患者的死亡率、实际手术失血量和术后并发症,为无血手术制定基于证据的指南。