在印度喀拉拉邦白纹伊蚊野生种群中检测基孔肯雅病毒。
Detection of Chikungunya virus in wild populations of Aedes albopictus in Kerala State, India.
作者信息
Kumar Narendran Pradeep, Sabesan Shanmugavelu, Krishnamoorthy Kaliannagounder, Jambulingam Purushothaman
机构信息
Vector Control Research Centre Field Station (ICMR), Kottayam, Kerala, India.
出版信息
Vector Borne Zoonotic Dis. 2012 Oct;12(10):907-11. doi: 10.1089/vbz.2012.0969. Epub 2012 Aug 27.
We detected Chikungunya virus (CHIKV) infection among wild populations of Aedes albopictus female specimens during the CHIKV outbreaks of 2009 and 2006 collected in different localities in Kerala State, India. The envelope 1 gene (E1) sequences of the virus isolate 2009 from the mosquito species showed close genetic relatedness (Kimura 2 Parameter genetic distance=0.0013) to CHIKV-positive isolates from human serum samples from the same area. E1 gene sequences from Ae. albopictus, as well as from human isolates, had the crucial non-synonymous C/T mutation at position 10670, leading to the A226V amino acid change. This natural inclination indicated the role of this mosquito species in the transmission of CHIKV during its recent outbreaks in Kerala State.
在2009年和2006年基孔肯雅病毒（CHIKV）疫情期间，我们在印度喀拉拉邦不同地点采集的白纹伊蚊雌性样本野生种群中检测到了CHIKV感染。2009年从该蚊种分离出的病毒的包膜1基因（E1）序列与同一地区人类血清样本中CHIKV阳性分离株显示出密切的遗传相关性（Kimura 2参数遗传距离 = 0.0013）。来自白纹伊蚊以及人类分离株的E1基因序列在第10670位有至关重要的非同义C/T突变，导致氨基酸A226V改变。这种自然倾向表明了该蚊种在喀拉拉邦近期疫情期间CHIKV传播中的作用。
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