Department of Gastroenterology, Baskent University, Ankara, Turkey.
Dis Esophagus. 2013 Nov-Dec;26(8):776-81. doi: 10.1111/j.1442-2050.2012.01395.x. Epub 2012 Aug 23.
Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease characterized with symptoms related to esophageal dysfunction and eosinophil-predominant inflammation. There has been a dramatic increase in the diagnosis of this disease in recent years. The primary objective of this study was to determine the frequency of EoE in adult patients who were evaluated by gastroenterologists in our clinic with esophageal symptoms. Between November 2010 and May 2011, 311 adult patients who were evaluated in our clinic with esophageal symptoms were enrolled prospectively. All patients underwent endoscopy and had biopsies taken. Gastroesophageal reflux disease was excluded by either proton pump inhibitory treatment or 24-hour ambulatory pH monitorization. The diagnosis was confirmed by one independent pathologist. Frequency of EoE in patients with esophageal symptoms was 2.6% (n = 8; four men and four women). Mean age at diagnosis was 40.2 ± 8 years. Heartburn was the predominant symptom in patients (75% of the patients), and 87.5% (n = 7) of patients had more than one symptom at diagnosis. Nearly 38% of the patients (n = 3) had a history of allergic disease. Endoscopic findings were as follows: transient/fixed esophageal rings (25%), white exudates (25%), and normal appearance (50%). Median number of circulating eosinophils was 208 (93-659)/mm(3) . Median number of intraepithelial eosinophils in proximal-middle 1/3 part and distal 1/3 part of esophagus were 0 (0-50)/hpf and 37 (16-50)/hpf, respectively. In conclusion, EoE is not rare in Turkey, and it should be considered in the differential diagnosis of patients with esophageal symptoms.
嗜酸粒细胞性食管炎（EoE）是一种慢性、免疫/抗原介导的食管疾病，其特征为与食管功能障碍和嗜酸性粒细胞为主的炎症相关的症状。近年来，这种疾病的诊断率显著增加。本研究的主要目的是确定在我们诊所因食管症状接受胃肠病学家评估的成年患者中 EoE 的频率。2010 年 11 月至 2011 年 5 月，我们前瞻性地招募了 311 名在我们诊所因食管症状接受评估的成年患者。所有患者均接受内镜检查并进行活检。通过质子泵抑制剂治疗或 24 小时动态 pH 监测排除胃食管反流病。诊断由一位独立病理学家确认。食管症状患者中 EoE 的频率为 2.6%（n = 8；4 名男性和 4 名女性）。诊断时的平均年龄为 40.2 ± 8 岁。烧心是患者的主要症状（75%的患者），87.5%（n = 7）的患者在诊断时有不止一种症状。近 38%的患者（n = 3）有过敏病史。内镜检查结果如下：短暂/固定性食管环（25%）、白色渗出物（25%）和正常外观（50%）。循环嗜酸性粒细胞中位数为 208（93-659）/mm3。食管近端-中段 1/3 和远端 1/3 上皮内嗜酸性粒细胞中位数分别为 0（0-50）/hpf 和 37（16-50）/hpf。总之，EoE 在土耳其并不罕见，应在食管症状患者的鉴别诊断中考虑到这种疾病。
