Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
Am J Obstet Gynecol. 2012 Nov;207(5):412.e1-10. doi: 10.1016/j.ajog.2012.08.008. Epub 2012 Aug 10.
Chemerin, a novel adipokine, has been implicated in adipogenesis, inflammation, and metabolism. The aims of this study were to determine the presence of chemerin in cord blood and its association with birthweight.
This cross-sectional study included the following: (1) twins with (n = 24) or without (n = 28) birthweight discordancy; and (2) singletons subclassified into small-for-gestational-age (SGA; n = 18); appropriate for gestational age (AGA; n = 33); and large-for-gestational-age (LGA; n = 8). Cord blood chemerin was determined. Parametric and nonparametric statistics were used for analysis.
The results of the study included the following: (1) within the discordant twins group, the median chemerin concentration was significantly lower in the SGA group than in their cotwins; (2) within singletons, the median chemerin concentration was significantly higher in the LGA than the AGA newborns; and (3) the regression model revealed that chemerin was independently associated with birthweight.
Cord blood chemerin is present in cord blood and its concentrations are positively correlated with birthweight. These novel findings support a role of adipokines in fetal growth.
趋化素是一种新型脂肪因子，参与脂肪生成、炎症和代谢过程。本研究旨在确定趋化素在脐血中的存在及其与出生体重的关系。
本横断面研究包括以下内容：（1）存在（n=24）或不存在（n=28）出生体重不相符的双胎；（2）分为小于胎龄儿（SGA；n=18）、适于胎龄儿（AGA；n=33）和大于胎龄儿（LGA；n=8）的单胎。测定脐血趋化素。采用参数和非参数统计分析。
本研究结果包括：（1）在不相符的双胎组中，SGA 组的趋化素浓度中位数明显低于其同卵双胎；（2）在单胎中，LGA 新生儿的趋化素浓度中位数明显高于 AGA 新生儿；（3）回归模型显示，趋化素与出生体重独立相关。
脐血中存在趋化素，其浓度与出生体重呈正相关。这些新发现支持脂肪因子在胎儿生长中的作用。
