抑郁症和痴呆症患者脑脊液中的S-腺苷甲硫氨酸：胃肠外和口服S-腺苷甲硫氨酸治疗的效果
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
作者信息
Bottiglieri T, Godfrey P, Flynn T, Carney M W, Toone B K, Reynolds E H
机构信息
Department of Neurology, King's College Hospital, London, United Kingdom.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1096-8. doi: 10.1136/jnnp.53.12.1096.
Abstract
Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either intravenously or orally is associated with a significant rise of CSF SAM, indicating that it crosses the blood-brain barrier in humans. These observations provide a rational basis for the antidepressant effect of SAM, which has been confirmed in several countries. CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment.
摘要
严重抑郁症患者脑脊液（CSF）中的S-腺苷甲硫氨酸（SAM）水平显著低于神经疾病对照组。静脉或口服SAM均会使脑脊液SAM显著升高，这表明SAM可穿越人体血脑屏障。这些观察结果为SAM的抗抑郁作用提供了合理依据，该作用已在多个国家得到证实。一组阿尔茨海默病痴呆患者的脑脊液SAM水平较低，这表明此类患者可能存在甲基化紊乱，因此需要进行SAM治疗试验。
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