抑郁症和痴呆症患者脑脊液中的S-腺苷甲硫氨酸：胃肠外和口服S-腺苷甲硫氨酸治疗的效果
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.
作者信息
Bottiglieri T, Godfrey P, Flynn T, Carney M W, Toone B K, Reynolds E H
机构信息
Department of Neurology, King's College Hospital, London, United Kingdom.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1096-8. doi: 10.1136/jnnp.53.12.1096.
Abstract
Cerebrospinal fluid (CSF) S-adenosylmethionine (SAM) levels were significantly lower in severely depressed patients than in a neurological control group. The administration of SAM either intravenously or orally is associated with a significant rise of CSF SAM, indicating that it crosses the blood-brain barrier in humans. These observations provide a rational basis for the antidepressant effect of SAM, which has been confirmed in several countries. CSF SAM levels were low in a group of patients with Alzheimer's dementia suggesting a possible disturbance of methylation in such patients and the need for trials of SAM treatment.
摘要
严重抑郁症患者脑脊液（CSF）中的S-腺苷甲硫氨酸（SAM）水平显著低于神经疾病对照组。静脉或口服SAM均会使脑脊液SAM显著升高，这表明SAM可穿越人体血脑屏障。这些观察结果为SAM的抗抑郁作用提供了合理依据，该作用已在多个国家得到证实。一组阿尔茨海默病痴呆患者的脑脊液SAM水平较低，这表明此类患者可能存在甲基化紊乱，因此需要进行SAM治疗试验。
相似文献
1
Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.抑郁症和痴呆症患者脑脊液中的S-腺苷甲硫氨酸：胃肠外和口服S-腺苷甲硫氨酸治疗的效果
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1096-8. doi: 10.1136/jnnp.53.12.1096.
2
S-adenosylmethionine levels in psychiatric and neurological disorders: a review.
Acta Neurol Scand Suppl. 1994;154:19-26. doi: 10.1111/j.1600-0404.1994.tb05405.x.
3
Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial.
Am J Psychiatry. 1990 May;147(5):591-5. doi: 10.1176/ajp.147.5.591.
4
S-adenosylmethionine treatment of depression: a controlled clinical trial.
Am J Psychiatry. 1988 Sep;145(9):1110-4. doi: 10.1176/ajp.145.9.1110.
5
CSF S-adenosylmethionine in neuropsychiatric disorders.
Lancet. 1991 Jul 13;338(8759):121. doi: 10.1016/0140-6736(91)90114-5.
6
S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease.S-腺苷甲硫氨酸在阿尔茨海默病患者的脑脊液中减少。
Neurodegener Dis. 2010;7(6):373-8. doi: 10.1159/000309657. Epub 2010 Jun 3.
7
Switch mechanism in affective illness and oral S-adenosylmethionine (SAM).
Br J Psychiatry. 1987 May;150:724-5. doi: 10.1192/bjp.150.5.724.
8
The influence of S-adenosylmethionine (SAM) on prolactin in depressed patients.
Int Clin Psychopharmacol. 1987 Apr;2(2):97-102. doi: 10.1097/00004850-198704000-00001.
9
Affective illness and S-adenosyl methionine: a preliminary report.
Clin Neuropharmacol. 1986;9(4):379-85. doi: 10.1097/00002826-198608000-00005.
10
The transmethylation cycle in the brain of Alzheimer patients.阿尔茨海默病患者大脑中的转甲基循环。
Neurosci Lett. 2005 Sep 30;386(2):69-71. doi: 10.1016/j.neulet.2005.03.073.
引用本文的文献
1
Bridging nutrition and neurology: malnutrition's role in perioperative neurocognitive disorders.架起营养与神经学之间的桥梁：营养不良在围手术期神经认知障碍中的作用
Front Nutr. 2025 Aug 13;12:1601021. doi: 10.3389/fnut.2025.1601021. eCollection 2025.
2
Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder.双等位基因NSUN3变异导致多种表型谱疾病：从孤立性视神经萎缩到严重早发性线粒体疾病。
Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):17. doi: 10.1167/iovs.66.6.17.
3
Targeting Divergent Pathways in the Nutritional Management of Depression.靶向抑郁症营养管理中的不同途径。
Nutrients. 2024 Aug 22;16(16):2806. doi: 10.3390/nu16162806.
4
Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease.一项针对轻度认知障碍或阿尔茨海默病所致痴呆患者的 S-腺苷甲硫氨酸的 II 期随机、多中心、双盲、安慰剂对照试验方案。
J Prev Alzheimers Dis. 2023;10(4):800-809. doi: 10.14283/jpad.2023.55.
5
Prenatal SAMe Treatment Changes via Epigenetic Mechanism/s USVs in Young Mice and Hippocampal Monoamines Turnover at Adulthood in a Mouse Model of Social Hierarchy and Depression.产前 SAMe 治疗通过表观遗传机制改变幼鼠的 USVs，并在社会等级和抑郁小鼠模型中改变成年海马单胺类递质的代谢。
Int J Mol Sci. 2023 Jun 27;24(13):10721. doi: 10.3390/ijms241310721.
6
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine.过量的 S-腺苷甲硫氨酸通过分解代谢为腺嘌呤来抑制甲基化。
Commun Biol. 2022 Apr 5;5(1):313. doi: 10.1038/s42003-022-03280-5.
7
Pharmacokinetic properties of a novel formulation of S-adenosyl-L-methionine phytate.新型 S-腺苷-L-蛋氨酸植酸盐制剂的药代动力学特性。
Amino Acids. 2021 Oct;53(10):1559-1568. doi: 10.1007/s00726-021-03076-7. Epub 2021 Sep 18.
8
Reduction of DNMT3a and RORA in the nucleus accumbens plays a causal role in post-traumatic stress disorder-like behavior: reversal by combinatorial epigenetic therapy.伏隔核中 DNMT3a 和 RORA 的减少在创伤后应激障碍样行为中起因果作用：组合表观遗传学治疗的逆转。
Mol Psychiatry. 2021 Dec;26(12):7481-7497. doi: 10.1038/s41380-021-01178-y. Epub 2021 Jul 12.
9
Metabolic disorder in Alzheimer's disease.阿尔茨海默病中的代谢紊乱。
Metab Brain Dis. 2021 Jun;36(5):781-813. doi: 10.1007/s11011-021-00673-z. Epub 2021 Feb 27.
10
Genome-wide association analysis reveals seed protein loci as determinants of variations in grain mold resistance in sorghum.全基因组关联分析揭示了种子蛋白基因座是高粱籽粒抗霉变性变异的决定因素。
Theor Appl Genet. 2021 Apr;134(4):1167-1184. doi: 10.1007/s00122-020-03762-2. Epub 2021 Jan 16.
本文引用的文献
1
Early clinical double-blind study with S-adenosyl-L-methionine: a new potential antidepressant.
Adv Biochem Psychopharmacol. 1982;32:175-80.
2
A radioenzymatic method for S-adenosyl-L-methionine determination in biological fluids.
Anal Biochem. 1984 Feb;137(1):217-20. doi: 10.1016/0003-2697(84)90373-7.
3
Methylation and mood.
Lancet. 1984 Jul 28;2(8396):196-8. doi: 10.1016/s0140-6736(84)90482-3.
4
Folic acid, S-adenosylmethionine and affective disorder.
Psychol Med. 1983 Nov;13(4):705-10. doi: 10.1017/s0033291700051394.
5
Serum folate values in 423 psychiatric patients.423名精神科患者的血清叶酸值。
Br Med J. 1967 Dec 2;4(5578):512-6. doi: 10.1136/bmj.4.5578.512.
6
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
Lancet. 1967 May 20;1(7499):1086-8. doi: 10.1016/s0140-6736(67)92654-2.
7
Switch mechanism in affective illness and oral S-adenosylmethionine (SAM).
Br J Psychiatry. 1987 May;150:724-5. doi: 10.1192/bjp.150.5.724.
8
Neuropharmacology of S-adenosyl-L-methionine.
Am J Med. 1987 Nov 20;83(5A):95-103. doi: 10.1016/0002-9343(87)90860-6.
9
S-adenosylmethionine in depression. A literature review and preliminary report.
Ala J Med Sci. 1988 Jul;25(3):306-13.
10
Transmethylation in depression.
Ala J Med Sci. 1988 Jul;25(3):296-301.
Zotero 插件