Department of Urology, Oregon Health & Science University, Portland, 97239, USA.
Curr Urol Rep. 2012 Dec;13(6):441-6. doi: 10.1007/s11934-012-0275-8.
There is an emerging evolution in the understanding of the relationship between the prostate and testosterone. It has long been generally believed that with testosterone replacement therapy (TRT), increasing serum testosterone levels led to prostatic growth and worsening of voiding dysfunction and associated complications. A new theory, the Saturation Model of Testosterone and its effect on the Prostate has gained attention. This theory suggests that the prostate's response to increasing levels of serum testosterone reaches a limit beyond which there is minimal effect. This model predicts that testosterone replacement therapy occurs above this saturation point, and replacing testosterone to eugonadal levels should not worsen prostate related benign disease. We evaluated the recent published data, with an emphasis on clinical studies done within the last 3 years, for the effects of testosterone supplementation on benign prostatic disease.
前列腺和睾酮之间的关系的理解正在出现新的发展。长期以来，人们普遍认为，随着睾酮替代疗法（TRT）的应用，血清睾酮水平的升高会导致前列腺生长，排尿功能障碍和相关并发症恶化。一种新的理论，即睾酮的饱和模型及其对前列腺的影响，引起了人们的关注。该理论表明，前列腺对血清睾酮水平升高的反应达到了一个极限，超过这个极限后，其影响就微乎其微了。该模型预测，睾酮替代疗法发生在这个饱和点之上，而将睾酮补充至正常水平不应使与前列腺相关的良性疾病恶化。我们评估了最近发表的数据，重点是过去 3 年内进行的临床研究，以了解睾酮补充对良性前列腺疾病的影响。
