Université Pierre et Marie Curie-Paris 06, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, Hôpital de la Salpêtrière, Paris, France.
Mov Disord. 2013 Jan;28(1):24-30. doi: 10.1002/mds.25032. Epub 2012 Aug 23.
Parkinson's disease is a common adult-onset neurodegenerative disorder whose pathogenesis remains essentially unknown. Currently, it is believed that the neurodegenerative process in Parkinson's disease is a combination of both cell-autonomous and non-cell-autonomous mechanisms. Proposed cell-autonomous mechanisms include alterations in mitochondrial bioenergetics, dysregulation of calcium homeostasis, and impaired turnover of mitochondria. As for the proposed non-cell-autonomous mechanisms, they involve prion-like behavior of misfolded proteins and neuroinflammation. This suggests that cell death in Parkinson's disease is caused by a multifactorial cascade of pathogenic events and argues that effective neuroprotective therapy for Parkinson's disease may have to rely on multiple drug interventions.
帕金森病是一种常见的成人发病的神经退行性疾病，其发病机制在很大程度上尚不清楚。目前，人们认为帕金森病的神经退行性过程是细胞自主和非细胞自主机制的结合。提出的细胞自主机制包括线粒体生物能学的改变、钙稳态失调和线粒体周转率受损。至于提出的非细胞自主机制，则涉及错误折叠蛋白的类朊病毒行为和神经炎症。这表明帕金森病中的细胞死亡是由多种致病事件的级联反应引起的，并表明有效的帕金森病神经保护治疗可能必须依赖于多种药物干预。
