• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

天然产物经鼻内给药在神经退行性疾病中的应用：综述

Application of Natural Products in Neurodegenerative Diseases by Intranasal Administration: A Review.

作者信息

Jin Yu, Ma Xinyu, Liu Shuo, Zong Shiyu, Cheng Yunlong, Zhang Hong, Wang Chunliu, Li Ye

机构信息

Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang 712046, China.

Key Laboratory of TCM Drug Delivery, Shaanxi Academy of Traditional Chinese Medicine, Xi'an 710001, China.

出版信息

Pharmaceutics. 2025 May 20;17(5):675. doi: 10.3390/pharmaceutics17050675.

DOI:10.3390/pharmaceutics17050675
PMID:40430965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114702/
Abstract

Natural products derived from traditional Chinese medicine have received significant attention as potential treatments for neurodegenerative disorders due to their wide availability, demonstrated efficacy, and favorable safety profiles. Intranasal delivery provides distinct advantages for targeting the central nervous system (CNS), enabling direct therapeutic agent delivery to the brain by bypassing the blood-brain barrier (BBB). This review evaluates natural products administered intranasally for neurodegenerative diseases (NDs), highlighting their therapeutic potential and addressing formulation challenges related to physicochemical properties. Strategic optimization approaches are proposed, including novel carrier systems, molecular modifications, and combination therapies. By discussing current difficulties and offering practical recommendations, this review aims to encourage further scholarly research and clinical application.

摘要

源自传统中药的天然产物因其广泛可得、已证实的疗效以及良好的安全性而作为神经退行性疾病的潜在治疗方法受到了极大关注。鼻内给药为靶向中枢神经系统（CNS）提供了独特优势，通过绕过血脑屏障（BBB）能够将治疗剂直接递送至大脑。本综述评估了经鼻内给药用于神经退行性疾病（NDs）的天然产物，突出了它们的治疗潜力，并探讨了与物理化学性质相关的制剂挑战。提出了策略性优化方法，包括新型载体系统、分子修饰和联合疗法。通过讨论当前的困难并提供实际建议，本综述旨在鼓励进一步的学术研究和临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/d82702f70017/pharmaceutics-17-00675-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/6c7979cce32f/pharmaceutics-17-00675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/9d61946c526f/pharmaceutics-17-00675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/0f2768970b4a/pharmaceutics-17-00675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/fa9842f26638/pharmaceutics-17-00675-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/39d8b23f12a7/pharmaceutics-17-00675-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/b515c4a6de0a/pharmaceutics-17-00675-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/d82702f70017/pharmaceutics-17-00675-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/6c7979cce32f/pharmaceutics-17-00675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/9d61946c526f/pharmaceutics-17-00675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/0f2768970b4a/pharmaceutics-17-00675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/fa9842f26638/pharmaceutics-17-00675-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/39d8b23f12a7/pharmaceutics-17-00675-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/b515c4a6de0a/pharmaceutics-17-00675-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc2/12114702/d82702f70017/pharmaceutics-17-00675-g007.jpg

相似文献

1
Application of Natural Products in Neurodegenerative Diseases by Intranasal Administration: A Review.天然产物经鼻内给药在神经退行性疾病中的应用：综述
Pharmaceutics. 2025 May 20;17(5):675. doi: 10.3390/pharmaceutics17050675.
2
Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies.从实验室到临床的鼻脑治疗转化中的卷积：成就与谬误。
J Control Release. 2022 Jan;341:782-811. doi: 10.1016/j.jconrel.2021.12.009. Epub 2021 Dec 11.
3
Natural products in neurodegenerative diseases: recent advances and future outlook.神经退行性疾病中的天然产物：最新进展与未来展望。
Front Pharmacol. 2025 Mar 19;16:1529194. doi: 10.3389/fphar.2025.1529194. eCollection 2025.
4
Navigating the Nose-to-Brain Route: A Systematic Review on Lipid-Based Nanocarriers for Central Nervous System Disorders.探索鼻-脑途径：基于脂质的纳米载体用于中枢神经系统疾病的系统综述
Pharmaceutics. 2024 Feb 27;16(3):329. doi: 10.3390/pharmaceutics16030329.
5
Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease.鼻内给药绕过血脑屏障，将治疗药物靶向输送至中枢神经系统，以治疗神经退行性疾病。
BMC Neurosci. 2008 Dec 10;9 Suppl 3(Suppl 3):S5. doi: 10.1186/1471-2202-9-S3-S5.
6
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook.用于靶向神经退行性疾病昼夜节律功能障碍的鼻内和吸入给药系统：现状与未来展望
Adv Drug Deliv Rev. 2025 May;220:115575. doi: 10.1016/j.addr.2025.115575. Epub 2025 Apr 2.
7
Nanotechnology-driven Microemulsion Based Intranasal Delivery to Neurotechnology-driven Neuralink: Strategies to Improve Management of Neurodegenerative Disorders.纳米技术驱动的微乳液经鼻给药向神经技术驱动的 Neuralink：改善神经退行性疾病管理的策略。
AAPS PharmSciTech. 2024 Sep 12;25(7):215. doi: 10.1208/s12249-024-02929-0.
8
Development of Brain Permeable Drugs and Novel Strategies to Overcome the Brain Barriers for Treatment Purposes.用于治疗目的的脑渗透性药物的开发及克服血脑屏障的新策略。
Curr Pharm Des. 2025 Apr 21. doi: 10.2174/0113816128386983250410092649.
9
Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges.天然产物在治疗神经退行性疾病方面的治疗潜力及其未来的前景和挑战。
Molecules. 2021 Sep 2;26(17):5327. doi: 10.3390/molecules26175327.
10
Intranasal treatment of neurodegenerative diseases and stroke.神经退行性疾病和中风的鼻内治疗。
Front Biosci (Schol Ed). 2012 Jan 1;4(1):74-89. doi: 10.2741/252.

本文引用的文献

1
Effect of eucalyptus oil on symptoms of allergic rhinitis: a systematic review.桉叶油对过敏性鼻炎症状的影响：一项系统评价
Indian J Otolaryngol Head Neck Surg. 2025 Feb;77(2):967-974. doi: 10.1007/s12070-024-05316-0. Epub 2025 Jan 3.
2
Vesicles: New Advances in the Treatment of Neurodegenerative Diseases.囊泡：神经退行性疾病治疗的新进展
Int J Mol Sci. 2024 Nov 26;25(23):12672. doi: 10.3390/ijms252312672.
3
Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis.
芍药苷通过激活HSF1-NRF1轴减轻帕金森病中的氧化应激和炎症。
Am J Chin Med. 2024;52(7):2131-2159. doi: 10.1142/S0192415X24500824. Epub 2024 Nov 30.
4
Diagnosis of multiple sclerosis: challenges and opportunities.多发性硬化症的诊断：挑战与机遇
Lancet Neurol. 2024 Oct;23(10):958-960. doi: 10.1016/S1474-4422(24)00368-5.
5
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle.人参皂苷Rg1通过消除RTP801和α-突触核蛋白自噬降解障碍来改善应激加剧的小鼠帕金森病。
Acta Pharmacol Sin. 2025 Feb;46(2):308-325. doi: 10.1038/s41401-024-01374-w. Epub 2024 Sep 3.
6
Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson's Models.芳樟醇和香叶醇在体外帕金森病模型中保护神经元免受氧化应激、炎症和铁蓄积的影响。
Antioxidants (Basel). 2024 Jul 29;13(8):917. doi: 10.3390/antiox13080917.
7
Rosemary extract activates oligodendrogenesis genes in mouse brain and improves learning and memory ability.迷迭香提取物可激活小鼠大脑中的少突胶质细胞生成基因，提高学习和记忆能力。
Biomed Pharmacother. 2024 Oct;179:117350. doi: 10.1016/j.biopha.2024.117350. Epub 2024 Aug 27.
8
Natural Products from Herbal Medicine Self-Assemble into Advanced Bioactive Materials.草药天然产物自组装成先进的生物活性材料。
Adv Sci (Weinh). 2024 Sep;11(35):e2403388. doi: 10.1002/advs.202403388. Epub 2024 Jul 21.
9
Paeonol ameliorates hyperlipidemia and autophagy in mice by regulating Nrf2 and AMPK/mTOR pathways.丹皮酚通过调控 Nrf2 和 AMPK/mTOR 通路改善小鼠高血脂和自噬。
Phytomedicine. 2024 Sep;132:155839. doi: 10.1016/j.phymed.2024.155839. Epub 2024 Jun 24.
10
Detoxification and underlying mechanisms towards toxic alkaloids by Traditional Chinese Medicine processing: A comprehensive review.中药炮制解毒及对毒性生物碱作用机制的研究进展。
Phytomedicine. 2024 Jul;129:155623. doi: 10.1016/j.phymed.2024.155623. Epub 2024 Apr 17.