Shigematsu Y, Nakai A, Kuriyama M, Kikawa Y, Konishi I, Sudo M, Itokawa Y
Department of Pediatrics, Fukui Medical School, Japan.
J Nutr Sci Vitaminol (Tokyo). 1990 Jun;36(3):209-15. doi: 10.3177/jnsv.36.209.
We recorded the auditory brainstem responses of rats fed a thiamin-deficient diet. The interpeak latencies between waves I and III, as well as those between waves I and IV, were significantly prolonged from day 24, while the latency of wave I was prolonged on day 26 of the thiamin-deficient diet. These delayed responses were corrected in 2 to 4 days after the initiation of daily intraperitoneal thiamin injections from day 32. The rats that were fed the thiamin-deficient diet, and then sacrificed on day 32, showed a decrease of total thiamin levels in the brain (26% of the level in control rat brains). Based on these results, we emphasize the value of the auditory brainstem response to detect thiamin deficiency.
我们记录了喂食硫胺素缺乏饮食的大鼠的听觉脑干反应。从第24天起，I波和III波之间以及I波和IV波之间的峰间潜伏期显著延长，而在硫胺素缺乏饮食的第26天，I波潜伏期延长。从第32天开始每日腹腔注射硫胺素后，这些延迟反应在2至4天内得到纠正。喂食硫胺素缺乏饮食并在第32天处死的大鼠，其大脑中硫胺素总水平降低（为对照大鼠大脑中水平的26%）。基于这些结果，我们强调听觉脑干反应在检测硫胺素缺乏方面的价值。
