Weber Michelle H, Kilpatrick Scott E, Bergman Simon
Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Diagn Cytopathol. 2012 Aug;40 Suppl 2:E140-3. doi: 10.1002/dc.21556. Epub 2010 Nov 2.
The epithelioid variant of myxofibrosarcoma is a rare but recently described entity. We report a case of an elderly woman who presented with a slowly enlarging mass of the right lower extremity. Fine-needle aspiration (FNA) cytology revealed a malignant epithelioid neoplasm. The smears of the aspirate material were highly cellular and contained a dominant population of cells with uniform round-to-oval nuclei and cytoplasmic vacuolization, arranged in loosely cohesive aggregates and linear arrays within a myxoid background. A second minor population of cells consisted of aggregates of bland spindled cells. On resection, the neoplasm proved to be an epithelioid myxofibrosarcoma. To our knowledge, the cytologic features of epithelioid myxofibrosarcoma have not previously been documented. Herein, we discuss the cytologic features of epithelioid myxofibrosarcoma as seen on FNA biopsy and its distinction from other epithelioid neoplasms of soft tissue.
黏液纤维肉瘤的上皮样变体是一种罕见但最近才被描述的实体。我们报告一例老年女性病例，其右下肢出现一个缓慢增大的肿块。细针穿刺（FNA）细胞学检查显示为恶性上皮样肿瘤。穿刺物涂片细胞丰富，主要细胞群具有均匀的圆形至椭圆形核及胞质空泡化，在黏液样背景中呈松散聚集和线性排列。第二小群细胞由温和的梭形细胞聚集体组成。切除后，肿瘤证实为上皮样黏液纤维肉瘤。据我们所知，上皮样黏液纤维肉瘤的细胞学特征此前尚未见文献记载。在此，我们讨论FNA活检所见上皮样黏液纤维肉瘤的细胞学特征及其与其他软组织上皮样肿瘤的鉴别。
