Tiaka Elisavet K, Papanas Nikolaos, Manolakis Anastassios C, Maltezos Efstratios
Int J Burns Trauma. 2011;1(1):68-76. Epub 2011 Sep 3.
Diabetic foot ulcers are still particularly difficult to heal. Therefore, preventing and therapeutic adjuncts are increasingly being explored. Nerve growth factor (NGF) is a promising agent exhibiting beneficial actions on both diabetic peripheral neuropathy, one of the main causes of foot ulcers, and on ulcer healing. Indeed, preclinical research in animal models of diabetes has revealed the trophic effect of NGF on small C-fibres, while phase 2 human trials have provided evidence for a favourable effect on sensory neuropathy. However, the results of a phase 3 trial were moderate and, therefore, not enough to encourage widespread use of NGF in the treatment of diabetic neuropathy. Available literature on the role of NGF on diabetic wound healing is sparse but encouraging. Exogenous supplementation of NGF or the use of alternative techniques to increase its endogenous expression could emerge as a protective and therapeutic modality for diabetic foot ulcers in addition to standard treatment and other growth factors. The present review provides an outlook on the role of NGF in the prophylaxis and treatment of diabetic foot ulcers.
糖尿病足溃疡仍然特别难以愈合。因此，人们越来越多地探索预防和辅助治疗方法。神经生长因子（NGF）是一种很有前景的药物，对糖尿病周围神经病变（足部溃疡的主要原因之一）和溃疡愈合都有有益作用。事实上，糖尿病动物模型的临床前研究已经揭示了NGF对小C纤维的营养作用，而2期人体试验已经为其对感觉神经病变的有利作用提供了证据。然而，3期试验的结果一般，因此不足以鼓励在糖尿病神经病变治疗中广泛使用NGF。关于NGF在糖尿病伤口愈合中作用的现有文献很少，但令人鼓舞。除了标准治疗和其他生长因子外，外源性补充NGF或使用替代技术增加其内源表达可能成为糖尿病足溃疡的一种保护和治疗方式。本综述对NGF在糖尿病足溃疡预防和治疗中的作用进行了展望。
