Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Psychosom Med. 2012 Sep;74(7):675-81. doi: 10.1097/PSY.0b013e318266d0f5. Epub 2012 Aug 28.
To examine whether the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in serotonin production, is associated with depressive symptoms.
The participants were 544 women and 442 men (aged 24-39 years) from the population-based Young Finns Study who participated in a medical examination in 2001 (including IDO and depression) and 2007 (follow-up assessment for depression).
At baseline, IDO was associated with depressive symptoms (in the total cohort: B = 0.23, p < .001; women: B = 0.20, p = .007; men: B = 0.29, p = .002; p for interaction = .19). IDO at baseline was also associated with depressive symptoms at follow-up in women (B = 0.17, p = .03), which remained significant when adjusting for any of the biologic and behavioral risk factors. Adjusting for body mass index attenuated the association by 6%. In the final model including all baseline variables, none of the risk factors (except for baseline depressive symptoms) were associated with depressive symptoms at follow-up.
These data suggest that IDO activity may be a risk factor for future depression especially in women. IDO-induced alterations in serotonergic function may offer one biologic explanation to the well-established associations between inflammation and depression.
探讨色氨酸 2,3-双加氧酶（IDO）的激活是否与抑郁症状有关，IDO 是一种参与血清素生成的酶。
参与者为来自基于人群的“年轻芬兰人研究”的 544 名女性和 442 名男性（年龄 24-39 岁），他们于 2001 年参加了一项医学检查（包括 IDO 和抑郁），并于 2007 年（进行抑郁随访评估）。
在基线时，IDO 与抑郁症状相关（在总队列中：B = 0.23，p <.001；女性：B = 0.20，p =.007；男性：B = 0.29，p =.002；p 交互作用=.19）。在女性中，基线时的 IDO 也与随访时的抑郁症状相关（B = 0.17，p =.03），当调整任何生物学和行为危险因素时，这种相关性仍然显著。调整体重指数后，关联度降低了 6%。在包含所有基线变量的最终模型中，除了基线时的抑郁症状外，没有任何危险因素与随访时的抑郁症状相关。
这些数据表明，IDO 活性可能是未来抑郁的一个危险因素，尤其是在女性中。IDO 诱导的 5-羟色胺能功能改变可能为炎症与抑郁之间已确立的关联提供了一种生物学解释。
