Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Clin Chest Med. 2012 Sep;33(3):431-43. doi: 10.1016/j.ccm.2012.05.005. Epub 2012 Jul 7.
This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.
本文总结了哮喘易感性和严重程度的全基因组研究的主要发现。两项大型荟萃分析确定了四个与哮喘发生一致相关的染色体区域。与哮喘亚表型（如肺功能、生物标志物水平和哮喘治疗反应）相关的基因可深入了解哮喘严重程度和疾病进展的机制。未来的遗传研究将结合全面表型哮喘患者的测序，以开发个性化治疗。
