Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
World Neurosurg. 2013 Feb;79(2):346-58. doi: 10.1016/j.wneu.2012.08.004. Epub 2012 Aug 25.
This study sought to review the articles published by Iranian neurosurgeons regarding their experiences during the Iraq-Iran conflict and compare them with reports from other conflicts.
We searched databases (MEDLINE and 2 Iranian databases, namely IranMedex and Scientific Information Database, up to December 2011) and references for relevant studies. The search terms included Iran, Iraq, conflict, battle, war, traumatic aneurysm (TA), posttraumatic epilepsy (PTE), brain infection, penetrating head wound (PHW), cerebrospinal fluid (CSF) leakage, spine injury, and peripheral nerve injury.
Twenty-eight articles were found that presented PHW, development of TA, infections, PTE, and peripheral nerve injuries. There were 2 different protocols for management of PHWs: radical surgery and minimal debridement protocol. The overall central nervous system infection rate was 10%. The cumulated incidence of TA was 6%.
Conservative minimal debridement of the wounds is indicated in patients with small entrance wounds, or those with Glasgow Coma Scale score ≥ 8 and no progressive neurological deficit. To diagnose TA before rupture, angiography is indicated in patients who have shells or bone fragments pass through the crowded vasculature, or have large/delayed hematoma, or if the surgeon has high index of suspicion based on neuroimaging and early debridement surgery. Surgery in a well-equipped nearby hospital after quick and safe evacuation of the victims by trained salvaging ancillary groups and the administration of broad-spectrum antibiotics and proper antiepileptics decrease the morbidity and mortality of casualties after PHW in war situations. The biases of the case selection, data collection, and confounders, and decreasing biases by conducting blinded controlled clinical trials, are discussed.
本研究旨在回顾伊朗神经外科医生发表的关于他们在两伊战争期间经历的文章,并与其他冲突的报告进行比较。
我们检索了数据库(MEDLINE 和 2 个伊朗数据库,即 IranMedex 和 Scientific Information Database,截至 2011 年 12 月)和相关研究的参考文献。检索词包括伊朗、伊拉克、冲突、战斗、战争、创伤性动脉瘤(TA)、创伤后癫痫(PTE)、脑感染、穿透性头部创伤(PHW)、脑脊液(CSF)漏、脊柱损伤和周围神经损伤。
共发现 28 篇文章报道了 PHW、TA 的发生、感染、PTE 和周围神经损伤。PHW 的处理有 2 种不同的方案:根治性手术和最小清创术方案。中枢神经系统感染总发生率为 10%。TA 的累积发生率为 6%。
对于入口较小的患者,或格拉斯哥昏迷量表评分≥8 分且无进行性神经功能缺损的患者,建议采用保守的最小清创术处理伤口。为了在破裂前诊断 TA,建议对有弹片或骨碎片穿过密集血管、有大/延迟性血肿、或根据神经影像学和早期清创手术有高度怀疑的患者进行血管造影。在经过训练的抢救辅助小组快速、安全地将伤员转移,并给予广谱抗生素和适当的抗癫痫药物后,在设备完善的附近医院进行手术,可以降低战争中 PHW 伤员的发病率和死亡率。讨论了病例选择、数据收集和混杂因素的偏倚,以及通过进行盲法对照临床试验减少偏倚的问题。