[破伤风疫苗接种后多灶性脱髓鞘性神经病变]

[Multifocal demyelinating neuropathy after tetanus vaccine].

作者信息

Paradiso G, Micheli F, Fernández Pardal M, Casas Parera I

机构信息

Hospital de Clínicas José de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

出版信息

Medicina (B Aires). 1990;50(1):52-4.

PMID:2292912

Abstract

A 39 year old man presenting multifocal demyelinating neuropathy (MFDN) is reported. Fifteen days before onset he had been vaccinated with 75 IU of tetanus toxoid. Although recent histories of vaccination or viral infection support the immunological hypothesis proposed for chronic acquired demyelinating neuropathies (CADN) it is reported for the first time in MFDN, suggesting that MFDN and CADN may share common pathophysiological mechanisms.

摘要

报告了一名39岁患有多灶性脱髓鞘性神经病（MFDN）的男性。在发病前15天，他接种了75国际单位的破伤风类毒素。尽管最近的疫苗接种或病毒感染史支持了针对慢性获得性脱髓鞘性神经病（CADN）提出的免疫假说，但这在MFDN中是首次报道，提示MFDN和CADN可能具有共同的病理生理机制。