Department of Chemistry, Islamic Azad University, Takestan Branch, Takestan, Iran.
IEEE Trans Nanobioscience. 2012 Sep;11(3):296-303. doi: 10.1109/TNB.2012.2197409. Epub 2012 Aug 24.
Nanoparticles of sulfonamide are prepared by the reaction of a benzenesulfonyl chloride with ammonia or an amine in acetonitrile solvent. The ultrasonic treatment was applied for preparation of nanoparticles. The produced sulfonamide nanoparticles were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), transmission electron microscope (TEM), scanning electron microscope (SEM), and other techniques. The antibacterial activities of sulfonamide nanoparticles derivatives tested against microorganism and compared with bulk forms (non-nano) conditions. The antibacterial activities of synthesized compounds were studied against two Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae, and two Gram-positive species, Staphylococcus aureus and Bacillus subtilis. These compounds antifungal activities have been studied against, Candida albicans, Aspergillus flavus, Aspergillus nigar.
磺胺类纳米粒子是通过苯磺酰氯与氨或胺在乙腈溶剂中的反应制备的。超声处理被应用于纳米粒子的制备。所制备的磺胺类纳米粒子通过 X 射线衍射（XRD）、红外光谱（IR）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）和其他技术进行了表征。磺胺类纳米粒子衍生物的抗菌活性被测试以对抗微生物，并与块状形式（非纳米）条件进行了比较。所合成的化合物的抗菌活性被研究了对两种革兰氏阴性菌，大肠杆菌，肺炎克雷伯菌，和两种革兰氏阳性菌，金黄色葡萄球菌和枯草芽孢杆菌。这些化合物的抗真菌活性已经被研究了对，白色念珠菌，黄曲霉，黑曲霉。
