Royal Perth Hospital, GPO Box X2213, Perth, Western Australia.
Br J Cancer. 2012 Sep 25;107(7):1125-30. doi: 10.1038/bjc.2012.363. Epub 2012 Aug 28.
Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relationship of TF and the metaplasia-adenoma-carcinoma sequence (MACS) of gastric cancer in a European population.
The expression of TF was examined immunohistochemically in 191 gastric tissue samples: (13: normal; 18: intestinal metaplasia; 160: gastric adenocarcinoma) from the European population.
TF was not expressed in normal gastric mucosal cells. A strong intensity of staining was found in intestinal metaplasia cells but in 2 of 18 samples. TF expression increased with advancing stage of gastric cancer (P<0.0001, Jonckheere's test for ordered medians). Stage 3-4 gastric cancers preferentially expressed TF (34%, P=0.04). In comparison with the Japanese study, TF was not expressed at a higher level in intestinal vs diffuse-type gastric cancers and expression had 'no prognostic' significance.
TF may be involved in tumour progression along the MACS of gastric cancer in the European population and is shown to start in precancerous lesions. However, clinical features may differ due to differences in biological features in the two populations, as reflected by differences in TF expression profile.
组织因子（TF）在正常组织止血中起作用，据报道在日本人群的肠型胃腺癌中异常表达，与较高的微血管密度和不良预后相关。这是第一项在欧洲人群中研究 TF 与胃癌的化生-腺瘤-癌序列（MACS）之间关系的研究。
在 191 个来自欧洲人群的胃组织样本中，采用免疫组织化学方法检测 TF 的表达情况：（13：正常；18：肠化生；160：胃腺癌）。
TF 在正常胃黏膜细胞中不表达。在肠化生细胞中发现了强烈的染色强度，但在 18 个样本中的 2 个样本中发现了这种情况。TF 表达随着胃癌的进展而增加（P<0.0001，Jonckheere 的有序中位数检验）。III-IV 期胃癌更倾向于表达 TF（34%，P=0.04）。与日本的研究相比，TF 在肠型与弥漫型胃腺癌中的表达水平并没有更高，并且表达“没有预后”意义。
TF 可能参与了欧洲人群胃腺癌的 MACS 肿瘤进展，并且在癌前病变中就已经开始表达。然而，由于两个人群的生物学特征存在差异，临床特征可能存在差异，这反映在 TF 表达谱的差异上。
