Mostaan Leila V, Yazdani Nasrin, Madani Seyed Ziaodin, Borghei Hasty, Mortazavi Shabnam, Ojani Leila, Mokhtari Zahra
Cancer Research Center, Omid Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.
Acta Med Iran. 2012;50(7):459-62.
Major salivary gland tumors are uncommon and the exact nature of these tumors is not obvious. This study was carried out to compare the histological results of intraoperative frozen sections against those of permanent reports for major salivary glands masses. One hundred thirty-nine patients with major salivary gland masses who were candidates for surgery underwent an intraoperative frozen section biopsy. A permanent histological examination was then performed for definite diagnosis and its result was compared with that of the frozen section. Sensitivity, specificity, accuracy and the positive and negative predictive values were analyzed. The frozen section had 98.4% sensitivity, 87% specificity, 97.1% accuracy, 98.4% positive predictive value and 87% negative predictive value in differentiating between non-neoplastic and neoplastic lesions. In addition, the frozen section's identification of a mass as either benign or malignant showed 98% sensitivity, 100% specificity, 99.2% accuracy, 100% positive predictive value and 99% negative predictive value. Based on the current study's findings, it can be suggested that the frozen section is considerably accurate in the diagnosis of malignant versus benign lesions of major salivary glands, regardless of the exact histopathological type of the malignant tumors.
大唾液腺肿瘤并不常见，这些肿瘤的确切性质并不明显。本研究旨在比较大唾液腺肿块术中冰冻切片与永久报告的组织学结果。139例拟行手术的大唾液腺肿块患者接受了术中冰冻切片活检。随后进行永久组织学检查以明确诊断，并将其结果与冰冻切片结果进行比较。分析了敏感性、特异性、准确性以及阳性和阴性预测值。在区分非肿瘤性和肿瘤性病变方面，冰冻切片的敏感性为98.4%，特异性为87%，准确性为97.1%，阳性预测值为98.4%，阴性预测值为87%。此外，冰冻切片将肿块鉴定为良性或恶性的敏感性为98%，特异性为100%，准确性为99.2%，阳性预测值为100%，阴性预测值为99%。根据本研究的结果，可以认为，无论恶性肿瘤的确切组织病理学类型如何，冰冻切片在大唾液腺良恶性病变的诊断中相当准确。
