Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, P.O. Box 80178, Utrecht 3508 TD, The Netherlands.
Occup Environ Med. 2012 Oct;69(10):759-66. doi: 10.1136/oemed-2011-100468. Epub 2012 Aug 27.
This study characterises neurocognitive domains that are affected by movement-induced time-varying magnetic fields (TVMF) within a static magnetic stray field (SMF) of a 7 Tesla (T) MRI scanner.
Using a double-blind randomised crossover design, 31 healthy volunteers were tested in a sham (0 T), low (0.5 T) and high (1.0 T) SMF exposure condition. Standardised head movements were made before every neurocognitive task to induce TVMF.
Of the six tested neurocognitive domains, we demonstrated that attention and concentration were negatively affected when exposed to TVMF within an SMF (varying from 5.0% to 21.1% per Tesla exposure, p<0.05), particular in situations were high working memory performance was required. In addition, visuospatial orientation was affected after exposure (46.7% per Tesla exposure, p=0.05).
Neurocognitive functioning is modulated when exposed to movement-induced TVMF within an SMF of a 7 T MRI scanner. Domains that were affected include attention/concentration and visuospatial orientation. Further studies are needed to better understand the mechanisms and possible practical safety and health implications of these acute neurocognitive effects.
本研究旨在描述在 7T 磁共振扫描仪的静态磁场（SMF）内运动引起的时变磁场（TVMF）对神经认知域的影响。
采用双盲随机交叉设计，31 名健康志愿者在假（0T）、低（0.5T）和高（1.0T）SMF 暴露条件下进行测试。在进行每项神经认知任务之前，都会进行标准的头部运动以产生 TVMF。
在所测试的六个神经认知域中，我们证明了当在 SMF 内暴露于 TVMF 时，注意力和集中力受到负面影响（每特斯拉暴露变化 5.0%至 21.1%，p<0.05），特别是在需要高工作记忆性能的情况下。此外，在暴露后视觉空间定向受到影响（每特斯拉暴露 46.7%，p=0.05）。
当在 7T MRI 扫描仪的 SMF 内暴露于运动引起的 TVMF 时，神经认知功能会发生调节。受影响的域包括注意力/集中力和视觉空间定向。需要进一步研究以更好地了解这些急性神经认知效应的机制以及可能的实际安全性和健康影响。
