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海普罗斯S治疗产后手术伤口并发症的临床有效性和安全性

[Clinical effectiveness and safety of Seaprose S in the treatment of complications of puerperal surgical wounds].

作者信息

Dindelli M, Potenza M T, Candotti G, Frigerio L, Pifarotti G

机构信息

I Clinica Ostetrico-Ginecologica, Università degli Studi L. Mangiagalli, Milano.

出版信息

Minerva Ginecol. 1990 Jul-Aug;42(7-8):313-5.

PMID:2293075
Abstract

The aim of the study was the assessment of the efficacy and safety of Seaprose S in women out patients from the maternity ward with infiltrated surgical wounds subsequent to vaginal birth or caesarean section. The semialkaline proteolithic enzyme Seaprose S, available in 30 mg tablets was administered at a dosage of 3 tablets a day for a period of 8 days. Thirty-two puerpera with a mean age of 31 years +/- 0.9 SE were admitted to the study with an episiotomic wound in 13 cases and a laparotomic wound consequent on caesarean section in the remaining 19 cases. The clinical situation deriving from the surgical wound resolved on average on the 4th day, in particular the swelling and the congestion of the wound had already diminished in the first days of treatment (p less than 0.01). Safety of Seaprose S was good considering that in no cases were side effects attributable to the treatment observed. In conclusion, from the data obtained in this study one may confirm the validity of Seaprose S in the treatment of laparotomic and episiotomic wounds.

摘要

本研究的目的是评估Seaprose S对产科病房出院的女性患者的疗效和安全性,这些患者在阴道分娩或剖宫产术后有手术伤口感染。半碱性蛋白水解酶Seaprose S有30毫克片剂,给药剂量为每日3片,疗程8天。32名平均年龄为31岁±0.9标准误的产妇参与了本研究,其中13例有会阴切开伤口,其余19例有剖宫产术后剖腹伤口。手术伤口导致的临床症状平均在第4天得到缓解,特别是在治疗的头几天伤口的肿胀和充血就已经减轻(p<0.01)。鉴于未观察到任何可归因于该治疗的副作用,Seaprose S的安全性良好。总之,从本研究获得的数据可以证实Seaprose S在治疗剖腹伤口和会阴切开伤口方面的有效性。

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