Vilibić-Cavlek Tatjana, Ljubin-Sternak Suncanica, Babić-Erceg Andrea, Sviben Mario, Mlinarić-Galinović Gordana
Odjel za virologiju, Hrvatski zavod za javno zdravstvo, Medicinski fakultet Sveucilisa u Zagrebu.
Lijec Vjesn. 2012 May-Jun;134(5-6):164-7.
Dengue is acute viral disease transmitted to humans by Aedes mosquitoes (Ae. aegypti, Ae. albopictus). Dengue virus belongs to the family Flaviviridae, genus Flavivirus. There are four dengue virus serotypes (1-4) which are maintained endemically. The disease is endemic in tropical and subtropical areas between latitudes 35 degrees N and 35 degrees S. Infections may be asymptomatic or may produce a wide spectrum of diseases: non-specific febrile illness, dengue fever, dengue haemorrhagic fever or dengue shock syndrome. For the first time in Croatia, Ae. albopictus was registered in Zagreb in October 2004. In autumn 2005, additional records of Ae. albopictus presence were made in many places along the Adriatic coast. During 2007, two cases of imported dengue fever were reported in Croatia, after which similar imported cases appeared continually. In August 2010, the first autochthonous case of dengue fever was recorded on the peninsula Peljesac. Though Croatia is not endemic for dengue, the existence of a corresponding vector and a latent threat by imported dengue cases demand state-of-the-art and timely diagnostics. The most commonly used methods in laboratory diagnosis of dengue infections involve detection of viral RNA, antigen detection and serologic methods (detection of antibodies).
登革热是一种由伊蚊（埃及伊蚊、白纹伊蚊）传播给人类的急性病毒性疾病。登革病毒属于黄病毒科黄病毒属。有四种登革病毒血清型（1 - 4型）呈地方性流行。该病在北纬35度至南纬35度之间的热带和亚热带地区流行。感染可能无症状，也可能引发多种疾病：非特异性发热疾病、登革热、登革出血热或登革休克综合征。2004年10月，白纹伊蚊首次在克罗地亚的萨格勒布被记录到。2005年秋季，亚得里亚海沿岸许多地方都有白纹伊蚊存在的更多记录。2007年，克罗地亚报告了两例输入性登革热病例，此后类似的输入性病例不断出现。2010年8月，在佩列沙茨半岛记录到首例本土登革热病例。尽管克罗地亚并非登革热流行地区，但存在相应病媒以及输入性登革热病例的潜在威胁，这就需要先进且及时的诊断方法。登革热感染实验室诊断中最常用的方法包括病毒RNA检测、抗原检测和血清学方法（抗体检测）。
