磷酸化蛋白作为生理效应器。
Phosphorylated proteins as physiological effectors.
作者信息
Greengard P
出版信息
Science. 1978 Jan 13;199(4325):146-52. doi: 10.1126/science.22932.
PMID:22932
Abstract
A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues. The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP. These and other observations suggest that many different classes of regulatory substances achieve certain of their biological effects by altering the phosphorylation of specific proteins.
摘要
多种神经递质、激素及其他调节因子会影响其靶组织中特定蛋白质的磷酸化。对蛋白质磷酸化具有这种共同作用的刺激类型包括许多并非通过环磷酸腺苷发挥作用的物质。这些以及其他观察结果表明，许多不同类别的调节物质通过改变特定蛋白质的磷酸化来实现其某些生物学效应。
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