Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
J Endocrinol Invest. 2013 May;36(5):326-30. doi: 10.3275/8581. Epub 2012 Aug 29.
As thyroid hormones are essential for normal pubertal growth and sexual development, TSH, free T₃ (FT₃) and free T₄ (FT₄) levels undergo progressive modification during childhood and puberty.
To establish thyroid hormone reference ranges in pre-pubertal children, pubertal adolescents, and adults and to evaluate any differences in thyroid function between overweight and normalweight pubertal subjects.
Chemiluminescent microparticle immunoassay was used to analyze TSH, FT₃ and FT₄ concentrations in serum samples from 508 children and adolescents aged 6 to 18 yr and 100 healthy adults aged 30 to 60 yr, and from 68 overweight pubertal adolescents. As data were not normally distributed, we compared them through non-parametric tests for independent samples and the reference ranges were assumed to lie between the 2.5th and 97.5th percentile.
We found a progressive and significant reduction in TSH, FT₃, and FT₄ levels in the three groups with increasing age. TSH levels were significantly higher in overweight patients than in the normal-weight group, but there were no significant differences for FT₃ or FT₄.
This study revealed significant differences in levels of thyroid hormone between different age groups and allowed us to establish normal reference ranges for pre-pubertal children between 0.87-5.19 mIU/l for TSH, 4.75-8.59 pmol/l for FT₃, and 13.09-20.61 pmol/l for FT₄, and for pubertal adolescents between 0.76- 4.51 mIU/l for TSH, 4.26-8.46 pmol/l for FT₃ and 10.94-19.09 pmol/l for FT₄.
甲状腺激素对正常青春期生长和性发育至关重要，因此 TSH、游离 T3（FT3）和游离 T4（FT4）水平在儿童期和青春期会逐渐发生改变。
建立儿童期前、青春期和成年期甲状腺激素参考范围，并评估超重和正常体重青春期受试者之间甲状腺功能的差异。
采用化学发光微粒子免疫分析法分析了 508 名 6 至 18 岁儿童和青少年以及 100 名 30 至 60 岁健康成年人的血清样本中的 TSH、FT3 和 FT4 浓度，以及 68 名超重青春期青少年的样本。由于数据不是正态分布的，我们通过独立样本的非参数检验进行了比较，参考范围被假定在第 2.5 百分位数和第 97.5 百分位数之间。
我们发现随着年龄的增加，三组人群的 TSH、FT3 和 FT4 水平逐渐显著降低。超重患者的 TSH 水平显著高于正常体重组，但 FT3 或 FT4 无显著差异。
本研究揭示了不同年龄组之间甲状腺激素水平的显著差异，并为我们建立了儿童期前儿童（0.87-5.19 mIU/l 为 TSH、4.75-8.59 pmol/l 为 FT3 和 13.09-20.61 pmol/l 为 FT4）和青春期青少年（0.76-4.51 mIU/l 为 TSH、4.26-8.46 pmol/l 为 FT3 和 10.94-19.09 pmol/l 为 FT4）的正常参考范围。
