Alqahatani M, Tamimi W, Aldaker M, Alenzi F, Tamim H, Alsadhan A
Pediatric Department, King Fahad Hospital of the University, Alkhobar.
Br J Biomed Sci. 2006;63(4):163-5. doi: 10.1080/09674845.2006.11732744.
This study aims to establish reference ranges for thyroid tests in young Saudi adults using the Centaur immunoassay method. Physical examination is performed and thyroid function tests include thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3). These are performed on 291 young Saudi adults (182 [63%] females and 109 [37%] males; average age: 27 years [range 18-50]). Clinical thyroid abnormality, related symptoms and/or abnormal thyroid function tests exclude a person from the study and thus a total of 276 subjects (171 [62%] females and 105 [38%] males) are used to establish the new reference ranges. Combined female and male ranges for TSH, FT4, and FT3 were found to be 0.48-6.30 miu/L (9.00-18.62 pmol/L and 3.39-6.85 pmol/L, respectively). Mean TSH and FT4 levels were significantly different (P<0.0001) from those quoted by the manufacturer. Ranges for TSH were 0.48-6.30 miu/L (female) and 0.52-4.89 miu/L (male) (P=0.08). Female ranges for FT4 and FT3 were 9.00-17.15 pmol/L and 3.39-5.82 pmol/L, respectively. Male ranges were 9.92-18.62 pmol/L (P=0.0001) and 4.36-6.85 pmol/L (P<0.0001). The range of TSH levels in the young local Saudi population proved to be higher than that quoted by the manufacturer. FT4 range was lower and narrower than that quoted by the manufacturer. Significant differences between female and male populations suggest that partitioning of the reference ranges by gender is necessary.
本研究旨在采用Centaur免疫测定法建立沙特年轻成年人甲状腺检查的参考范围。进行体格检查，甲状腺功能测试包括促甲状腺激素（TSH）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）。对291名沙特年轻成年人（182名[63%]女性和109名[37%]男性；平均年龄：27岁[范围18 - 50岁]）进行了这些测试。临床甲状腺异常、相关症状和/或甲状腺功能测试异常会将一个人排除在研究之外，因此共有276名受试者（171名[62%]女性和105名[38%]男性）被用于建立新的参考范围。TSH、FT4和FT3的男女合并参考范围分别为0.48 - 6.30 mIU/L（9.00 - 18.62 pmol/L和3.39 - 6.85 pmol/L）。TSH和FT4的平均水平与制造商引用的水平有显著差异（P<0.0001）。TSH的参考范围为0.48 - 6.30 mIU/L（女性）和0.52 - 4.89 mIU/L（男性）（P = 0.08）。女性FT4和FT3的参考范围分别为9.00 - 17.15 pmol/L和3.39 - 5.82 pmol/L。男性参考范围分别为9.92 - 18.62 pmol/L（P = 0.0001）和4.36 - 6.85 pmol/L（P<0.0001）。沙特当地年轻人群的TSH水平范围高于制造商引用的范围。FT4范围低于且窄于制造商引用的范围。男女群体之间的显著差异表明按性别划分参考范围是必要的。
