通过对卤代吡啶基（4′-甲氧基苯基）碘𬭩对甲苯磺酸盐进行放射性氟化反应，选择性合成无载体添加的 2- 和 3-[18F]氟代吡啶。
Selective syntheses of no-carrier-added 2- and 3-[18F]fluorohalopyridines through the radiofluorination of halopyridinyl(4'-methoxyphenyl)iodonium tosylates.
机构信息
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, MD 20892-1003, USA.
出版信息
Chem Commun (Camb). 2012 Oct 11;48(79):9921-3. doi: 10.1039/c2cc35005j. Epub 2012 Aug 30.
Abstract
No-carrier-added 2- and 3-[(18)F]fluorohalopyridines were readily synthesized as potentially useful labeling synthons for prospective PET radiotracers through the selective radiofluorination of halopyridinyl(4'-methoxyphenyl)iodonium tosylates, themselves conveniently prepared in a single pot from iodohalopyridines.
摘要
无载体添加的 2- 和 3-[(18)F]氟代卤代吡啶很容易通过选择性放射性氟化卤代吡啶基(4'-甲氧基苯基)碘𬭩对甲苯磺酸盐来合成，这些碘𬭩盐本身可以从卤代吡啶中方便地一锅法制备，是潜在有用的正电子发射断层扫描放射性示踪剂标记前体。
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