Cristoffanini A, Zapata C, León A, Salas P
Instituto de Investigaciones Hematológicas Rodolfo Virchow, Facultad de Medicina, Universidad Austral de Chile, Valdivia.
Rev Med Chil. 1990 May;118(5):522-9.
Neoplasia may develop in patients with malignant hematologic disorders, during remission after radio and/or chemotherapy. A multifactorial origin related to therapy may be postulated. From 1978 to 1987, among 142 patients with malignant hematologic disorders (Hodgkin lymphoma 33, non-Hodgkin lymphoma 51, Multiple Myeloma 35 and Chronic Myeloid Leukemia 31) we observed 3 patients developing another neoplasia. An additional patient with acute non-lymphatic leukemia had been submitted to chemotherapy for gastric cancer. Four other patients with double neoplasia, one of them a hematologic one, had not been submitted to chemotherapy. The lack of national registries for neoplastic diseases precludes an estimation of the odd ratios involved in our findings.
肿瘤可能在恶性血液病患者接受放疗和/或化疗后的缓解期发生。可以假定其起源与治疗相关的多种因素有关。1978年至1987年间，在142例恶性血液病患者（霍奇金淋巴瘤33例、非霍奇金淋巴瘤51例、多发性骨髓瘤35例和慢性粒细胞白血病31例）中，我们观察到3例患者发生了另一种肿瘤。另有1例急性非淋巴细胞白血病患者曾因胃癌接受化疗。其他4例患有双重肿瘤的患者，其中1例为血液系统肿瘤，未接受化疗。由于缺乏肿瘤疾病的国家登记系统，无法对我们研究结果中的比值比进行估计。
