Shone G R, Yardley M P, Knight L C
Dept. of Otolaryngology, University of Wales, Cardiff, United Kingdom.
Rhinology. 1990 Dec;28(4):265-8.
A prospective trial was carried out to assess whether mucociliary clearance (MCC) is either adversely affected or improved in the early weeks after nasal surgery. Three different subgroups of patients were studied: those having septoplasty, nasal polypectomy, or turbinectomy. MCC was assessed by the saccharine transport method. 40% of patients with deviated nasal septum, 59% of patients with nasal polyps, and 75% of patients with chronic rhinitis refractory to medical treatment (turbinectomy group) had abnormal MCC pre-operatively. At three weeks after operation there was no significant improvement or deterioration in MCC either in the whole patient population or in any of the three subgroups. Persisting mucociliary dysfunction may be an important factor in causing post-operative stasis of secretions, crusting, secondary infection, delayed healing, and patient discomfort.
开展了一项前瞻性试验,以评估鼻手术后最初几周内黏液纤毛清除功能(MCC)是受到不利影响还是得到改善。研究了三组不同的患者:接受鼻中隔成形术、鼻息肉切除术或鼻甲切除术的患者。通过糖精转运法评估MCC。术前,40%的鼻中隔偏曲患者、59%的鼻息肉患者和75%药物治疗无效的慢性鼻炎患者(鼻甲切除术组)的MCC异常。术后三周,全患者群体以及三个亚组中的任何一组,MCC均无显著改善或恶化。持续存在的黏液纤毛功能障碍可能是导致术后分泌物淤滞、结痂、继发感染、愈合延迟和患者不适的重要因素。