肾脏药物转运体的内分泌和代谢调节。
Endocrine and metabolic regulation of renal drug transporters.
机构信息
Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854-8020, USA.
出版信息
J Biochem Mol Toxicol. 2012 Oct;26(10):407-21. doi: 10.1002/jbt.21435. Epub 2012 Aug 29.
Abstract
Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the efficacy and toxicity of chemicals. Studies in experimental animals have revealed distinct patterns of renal transporter expression in response to sex hormones, pregnancy, and growth hormone. Likewise, a number of disease states including diabetes, obesity, and cholestasis alter the expression of kidney transporters. The goal of this review is to provide an overview of the major xenobiotic transporters expressed in the kidneys and an understanding of metabolic conditions and hormonal factors that regulate their expression and function.
摘要
肾外排转运体是影响化学物质经尿液分泌和重吸收的重要决定因素。除了肾小球滤过，这些过程对于各种药物和毒素的整体肾脏清除率至关重要。肾脏转运体水平和功能的改变会影响化学物质的疗效和毒性。实验动物研究揭示了肾脏转运体表达对性激素、妊娠和生长激素的反应存在明显的模式。同样，许多疾病状态，包括糖尿病、肥胖症和胆汁淤积症，也会改变肾脏转运体的表达。本综述的目的是提供一个概述在肾脏中表达的主要外排转运体，并了解调节其表达和功能的代谢状况和激素因素。
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