• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization.通过对一个表位侧翼氨基酸的修饰，可以通过基于腺病毒的免疫接种诱导 Friend 逆转录病毒特异性 CD8+T 细胞。
J Virol. 2012 Nov;86(22):12422-5. doi: 10.1128/JVI.01607-12. Epub 2012 Aug 29.
2
Immunodominance of Adenovirus-Derived CD8 T Cell Epitopes Interferes with the Induction of Transgene-Specific Immunity in Adenovirus-Based Immunization.腺病毒衍生的CD8 T细胞表位的免疫显性干扰基于腺病毒免疫中转基因特异性免疫的诱导。
J Virol. 2017 Sep 27;91(20). doi: 10.1128/JVI.01184-17. Print 2017 Oct 15.
3
Comparative Evaluation of the Vaccine Efficacies of Three Adenovirus-Based Vector Types in the Friend Retrovirus Infection Model.三种腺病毒载体类型在 Friend 逆转录病毒感染模型中的疫苗效力比较评估。
J Virol. 2019 Oct 15;93(21). doi: 10.1128/JVI.01155-19. Print 2019 Nov 1.
4
Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery.基于腺病毒的免疫接种诱导复杂免疫反应并对逆转录病毒攻击产生强大保护作用，这取决于疫苗接种的顺序。
Retrovirology. 2017 Feb 6;14(1):8. doi: 10.1186/s12977-017-0336-7.
5
Interference of retroviral envelope with vaccine-induced CD8 T cell responses is relieved by co-administration of cytokine-encoding vectors.通过共同给予细胞因子编码载体可减轻逆转录病毒包膜对疫苗诱导的CD8 T细胞反应的干扰。
Retrovirology. 2017 Apr 27;14(1):28. doi: 10.1186/s12977-017-0352-7.
6
Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection.用编码逆转录病毒包膜的鼠巨细胞病毒载体免疫可强烈保护免受 Friend 逆转录病毒攻击感染。
PLoS Pathog. 2019 Sep 30;15(9):e1008043. doi: 10.1371/journal.ppat.1008043. eCollection 2019 Sep.
7
Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity.鉴定弗氏小鼠白血病病毒p15gag中一种保护性CD4 + T细胞表位以及靶向质膜的基质蛋白在免疫原性中的作用。
J Virol. 2004 Jun;78(12):6322-34. doi: 10.1128/JVI.78.12.6322-6334.2004.
8
Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease.肽诱导CD8 + T细胞缺陷小鼠对Friend逆转录病毒诱导疾病的免疫保护。
Int Immunol. 2006 Jan;18(1):183-98. doi: 10.1093/intimm/dxh361. Epub 2005 Dec 13.
9
Role of natural killer cells in resistance against friend retrovirus-induced leukemia.自然杀伤细胞在抗Friend逆转录病毒诱导的白血病中的作用。
J Virol. 2001 Apr;75(7):3152-63. doi: 10.1128/JVI.75.7.3152-3163.2001.
10
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.从Friend、莫洛尼和劳舍尔鼠白血病病毒诱导的肿瘤中鉴定出FBL-3白血病中由gag编码的细胞毒性T淋巴细胞表位，该表位为上述三种病毒所共有。
J Virol. 1996 Nov;70(11):7773-82. doi: 10.1128/JVI.70.11.7773-7782.1996.

引用本文的文献

1
Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases.黏膜肿瘤疫苗传递内源性肿瘤抗原可预防肺部乳腺癌转移。
J Immunother Cancer. 2024 Mar 7;12(3):e008652. doi: 10.1136/jitc-2023-008652.
2
A detailed analysis of F-MuLV- and SFFV-infected cells in Friend virus-infected mice reveals the contribution of both F-MuLV- and SFFV-infected cells to the interleukin-10 host response.对 Friend 病毒感染小鼠中 F-MuLV 和 SFFV 感染细胞的详细分析揭示了 F-MuLV 和 SFFV 感染细胞对白细胞介素-10 宿主反应的贡献。
Retrovirology. 2022 Dec 16;19(1):29. doi: 10.1186/s12977-022-00613-4.
3
Perspectives in Peptide-Based Vaccination Strategies for Syndrome Coronavirus 2 Pandemic.2019冠状病毒病大流行中基于肽的疫苗接种策略展望
Front Pharmacol. 2020 Dec 3;11:578382. doi: 10.3389/fphar.2020.578382. eCollection 2020.
4
Immunization with a murine cytomegalovirus based vector encoding retrovirus envelope confers strong protection from Friend retrovirus challenge infection.用编码逆转录病毒包膜的鼠巨细胞病毒载体免疫可强烈保护免受 Friend 逆转录病毒攻击感染。
PLoS Pathog. 2019 Sep 30;15(9):e1008043. doi: 10.1371/journal.ppat.1008043. eCollection 2019 Sep.
5
Comparative Evaluation of the Vaccine Efficacies of Three Adenovirus-Based Vector Types in the Friend Retrovirus Infection Model.三种腺病毒载体类型在 Friend 逆转录病毒感染模型中的疫苗效力比较评估。
J Virol. 2019 Oct 15;93(21). doi: 10.1128/JVI.01155-19. Print 2019 Nov 1.
6
Immunodominance of Adenovirus-Derived CD8 T Cell Epitopes Interferes with the Induction of Transgene-Specific Immunity in Adenovirus-Based Immunization.腺病毒衍生的CD8 T细胞表位的免疫显性干扰基于腺病毒免疫中转基因特异性免疫的诱导。
J Virol. 2017 Sep 27;91(20). doi: 10.1128/JVI.01184-17. Print 2017 Oct 15.
7
Interference of retroviral envelope with vaccine-induced CD8 T cell responses is relieved by co-administration of cytokine-encoding vectors.通过共同给予细胞因子编码载体可减轻逆转录病毒包膜对疫苗诱导的CD8 T细胞反应的干扰。
Retrovirology. 2017 Apr 27;14(1):28. doi: 10.1186/s12977-017-0352-7.
8
Induction of complex immune responses and strong protection against retrovirus challenge by adenovirus-based immunization depends on the order of vaccine delivery.基于腺病毒的免疫接种诱导复杂免疫反应并对逆转录病毒攻击产生强大保护作用，这取决于疫苗接种的顺序。
Retrovirology. 2017 Feb 6;14(1):8. doi: 10.1186/s12977-017-0336-7.
9
Interleukin-encoding adenoviral vectors as genetic adjuvant for vaccination against retroviral infection.白细胞介素编码腺病毒载体作为逆转录病毒感染疫苗的遗传佐剂。
PLoS One. 2013 Dec 4;8(12):e82528. doi: 10.1371/journal.pone.0082528. eCollection 2013.
10
Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.新型人类癌症抗原POTE中HLA - A2.1限制性CTL表位的鉴定与增强
PLoS One. 2013 Jun 4;8(6):e64365. doi: 10.1371/journal.pone.0064365. Print 2013.

本文引用的文献

1
High-capacity adenoviral vectors circumvent the limitations of ΔE1 and ΔE1/ΔE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses.高容量腺病毒载体规避了 ΔE1 和 ΔE1/ΔE3 腺病毒载体的局限性，可诱导多特异性转基因产物定向的 CD8 T 细胞反应。
J Gene Med. 2011 Dec;13(12):648-57. doi: 10.1002/jgm.1629.
2
Vaccination with an adenoviral vector that encodes and displays a retroviral antigen induces improved neutralizing antibody and CD4+ T-cell responses and confers enhanced protection.接种编码和展示逆转录病毒抗原的腺病毒载体可诱导改善的中和抗体和 CD4+ T 细胞应答，并提供增强的保护。
J Virol. 2010 Feb;84(4):1967-76. doi: 10.1128/JVI.01840-09. Epub 2009 Dec 9.
3
Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20 -- 38) peptide displayed on bacterial thioredoxin.由展示在细菌硫氧还蛋白上的HPV16 L2（20 - 38）肽串联重复序列诱导产生的强效抗人乳头瘤病毒免疫反应。
Vaccine. 2009 Mar 18;27(13):1949-56. doi: 10.1016/j.vaccine.2009.01.102. Epub 2009 Jan 31.
4
Co-immunization of mice with a retroviral DNA vaccine and GITRL-encoding plasmid augments vaccine-induced protection against retrovirus infection.用逆转录病毒DNA疫苗和编码GITRL的质粒对小鼠进行联合免疫，可增强疫苗诱导的抗逆转录病毒感染保护作用。
Viral Immunol. 2008 Dec;21(4):459-67. doi: 10.1089/vim.2008.0046.
5
NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11.NetMHC-3.0：可通过网络访问的、对长度为8至11个氨基酸的人、小鼠和猴MHC I类肽亲和力的准确预测。
Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W509-12. doi: 10.1093/nar/gkn202. Epub 2008 May 7.
6
The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver.小鼠肝脏对腺病毒、辅助依赖型腺病毒和腺相关病毒的宿主反应。
Mol Ther. 2008 May;16(5):931-41. doi: 10.1038/mt.2008.37. Epub 2008 Mar 18.
7
Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies.评估用于开发改进的腺病毒载体抗逆转录病毒疫苗策略的Friend病毒模型。
Vaccine. 2008 Jan 30;26(5):716-26. doi: 10.1016/j.vaccine.2007.11.050. Epub 2007 Dec 5.
8
Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo.腺病毒感染引发快速的、由髓样分化因子88（MyD88）调控的转录组反应，这对体内急性期和适应性免疫反应至关重要。
J Virol. 2007 Feb;81(4):1796-812. doi: 10.1128/JVI.01936-06. Epub 2006 Nov 22.
9
Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection.弗氏逆转录病毒感染期间CD8 +效应T细胞反应和诱导性CD4 +调节性T细胞反应的动力学
Eur J Immunol. 2006 Oct;36(10):2658-70. doi: 10.1002/eji.200636059.
10
Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies.能够呈现HIV-1 V3环冠部且构象适合产生447-52D样抗体的免疫原的设计。
Biochem J. 2006 Nov 1;399(3):483-91. doi: 10.1042/BJ20060588.

通过对一个表位侧翼氨基酸的修饰，可以通过基于腺病毒的免疫接种诱导 Friend 逆转录病毒特异性 CD8+T 细胞。

Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization.

机构信息

Institute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

出版信息

J Virol. 2012 Nov;86(22):12422-5. doi: 10.1128/JVI.01607-12. Epub 2012 Aug 29.

DOI:10.1128/JVI.01607-12
PMID:22933287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486454/
Abstract

While Friend retrovirus-infected mice readily mount a vigorous CD8(+) T cell response to the leader-gag-derived peptide GagL(85-93), no GagL(85-93)-specific T cells were detectable in mice immunized against Friend virus (FV) with viral vectors or DNA vaccines. By exchanging one epitope-flanking amino acid or using a scaffold protein we were able to demonstrate for the first time the induction of GagL(85-93)-specific CD8(+) T cells by genetic vaccination and show their high protective effect against FV challenge infection.

摘要

虽然 Friend 逆转录病毒感染的小鼠很容易对来自 leader-gag 衍生肽 GagL(85-93)的强烈 CD8(+) T 细胞反应，但在用病毒载体或 DNA 疫苗对 Friend 病毒 (FV) 进行免疫的小鼠中，未检测到针对 GagL(85-93)的 T 细胞。通过交换一个表位侧翼氨基酸或使用支架蛋白，我们首次能够证明通过基因疫苗接种诱导 GagL(85-93)-特异性 CD8(+) T 细胞，并显示它们对 FV 攻击感染的高度保护作用。