Wüsthoff Linda E, Waal Helge, Gråwe Rolf W
Norwegian Center for Addiction Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Subst Abuse. 2012;6:95-106. doi: 10.4137/SART.S9245. Epub 2012 Aug 16.
Research on treatments for patients with co-occurring psychiatric and substance use disorders is of core importance and at the same time highly challenging as it includes patients that are normally excluded from clinical studies. Such research may require methodological adaptations which in turn create new challenges. However, the challenges that arise in such studies are insufficiently discussed in the literature. The aim of this methodology paper is, firstly, to discuss the methodological adaptations that may be required in such research; secondly, to describe how such adaptations created new challenges in a group-randomized clinical trial on Integrated Treatment amongst patients with co-occurring psychiatric and substance use disorders. We also discuss how these challenges might be understood and highlight lessons for future research in this field.
NCT00447733.
对同时患有精神疾病和物质使用障碍的患者进行治疗的研究至关重要，但同时极具挑战性，因为这类研究纳入了通常被排除在临床研究之外的患者。此类研究可能需要方法学上的调整，而这反过来又带来了新的挑战。然而，文献中对这类研究中出现的挑战讨论不足。本方法学论文的目的，首先是讨论此类研究可能需要的方法学调整；其次，描述这些调整如何在一项针对同时患有精神疾病和物质使用障碍患者的综合治疗的群组随机临床试验中带来新的挑战。我们还将讨论如何理解这些挑战，并突出该领域未来研究的经验教训。
NCT00447733。
