硫利达嗪对卡马西平及其活性代谢物卡马西平-10,11-环氧化物的血浆浓度无影响。
No effect of thioridazine on plasma concentrations of carbamazepine and its active metabolite carbamazepine-10,11-epoxide.
作者信息
Spina E, Amendola D'Agostino A M, Ioculano M P, Oteri G, Fazio A, Pisani F
机构信息
Institute of Pharmacology, University of Messina, Italy.
出版信息
Ther Drug Monit. 1990 Sep;12(5):511-3. doi: 10.1097/00007691-199009000-00017.
Abstract
The effect of an oral treatment with thioridazine (100 or 200 mg daily) on plasma concentrations of carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) was studied in eight epileptic patients stabilized on CBZ therapy. No significant changes in steady-state plasma levels of CBZ and CBZ-E occurred, suggesting that CBZ metabolism is not apparently affected by thioridazine.
摘要
在8名接受卡马西平（CBZ）治疗病情稳定的癫痫患者中，研究了口服硫利达嗪（每日100或200毫克）对卡马西平（CBZ）及其活性代谢物卡马西平-10,11-环氧化物（CBZ-E）血浆浓度的影响。CBZ和CBZ-E的稳态血浆水平未发生显著变化，这表明硫利达嗪对CBZ代谢无明显影响。
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