Zhou Hong, Zhu Jun, Zhu Guoqiang
College of Veterinary Medicine, Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou 225009, China.
Wei Sheng Wu Xue Bao. 2012 Jun 4;52(6):679-86.
Animal-originated enterotoxigenic Escherichia coli (ETEC) are major pathogens resulting in newborn and young animal diarrhea. Adhesins and enterotoxins, both are essential for the pathogenicity of ETEC, are two major virulent factors of ETEC. Adhesion of animal-originated ETEC fimbrial adhesins (mainly including K88, K99, 987P, F18, F17 and F41) to intestinal epithelial cells is the initial and most important step involved in the ETEC infection. From the 1960s, studies on ETEC fimbrial genes, structure, biosynthesis, regulation of expression, interaction between fimbriae and host receptors have helped to better understand the biology and role of these organelles in pathogenesis. These studies also provide insight into new diagnostic tools and development of vaccines and inhibitors of ETEC colonization.
动物源产肠毒素大肠杆菌（ETEC）是导致新生动物和幼龄动物腹泻的主要病原体。黏附素和肠毒素是ETEC的两个主要毒力因子，二者对ETEC的致病性均至关重要。动物源ETEC菌毛黏附素（主要包括K88、K99、987P、F18、F17和F41）与肠道上皮细胞的黏附是ETEC感染过程中最初也是最重要的一步。自20世纪60年代以来，对ETEC菌毛基因、结构、生物合成、表达调控以及菌毛与宿主受体之间相互作用的研究，有助于更好地理解这些细胞器在发病机制中的生物学特性和作用。这些研究还为开发新的诊断工具、ETEC定植疫苗和抑制剂提供了思路。
