[阻塞性睡眠呼吸暂停低通气综合征患者行悬雍垂腭咽成形术（H-UPPP）后呼吸紊乱指数、最低血氧饱和度及内皮素-1的研究]

[The study on AHI, LSaO2 and ET-1 in patients with obstructive sleep apnea-hypopnea syndrome after H-UPPP].

作者信息

Wu Xiaosong, Yu Yi, Hu Dongli

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Jun;26(12):539-41.

PMID:22934425

Abstract

OBJECTIVE

To explore the treatment effect of H-UPPP on patients with obstructive sleep apnea hypopnea syndrome (OSAHS).

METHOD

Seventy-nine patients were enrolled in our study. Among which 49 patients were done with H-UPPP, and the other 30 patients were done with UPPP. AHI and LSaO2 were monitored by polysomnography and plasma endothelins-1 were tested with enzyme linked immunosorbent assay (ELISA) before and after operation.

RESULT

Forty-one patients were improved with reduced snoring and daytime sleepiness one year after operation in H-UPPP group,and the overall efficiency was 83.7%. Twenty-six patients were improved with reduced snoring and daytime sleepiness one year after operation in UPPP group, and the overall efficiency was 86.7%. There were significant differences of AHI, LSaO2 and ET-1 before and after operation between the two groups. Negative correlation was showed between AHI and LSaO2, also between LSaO2 and ET-1.

CONCLUSION

Both H-UPPP and UPPP were proved to be effective to patients with OSAHS. The perioperative complications with H-UPPP was less than UPPP.

摘要

目的

探讨改良悬雍垂腭咽成形术（H-UPPP）治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的疗效。

方法

选取79例患者纳入本研究。其中49例行改良悬雍垂腭咽成形术，另外30例行悬雍垂腭咽成形术（UPPP）。术前及术后通过多导睡眠图监测呼吸暂停低通气指数（AHI）和最低血氧饱和度（LSaO2），采用酶联免疫吸附测定（ELISA）检测血浆内皮素-1。

结果

改良悬雍垂腭咽成形术组术后1年有41例患者打鼾及日间嗜睡症状改善，总有效率为83.7%。悬雍垂腭咽成形术组术后1年有26例患者打鼾及日间嗜睡症状改善，总有效率为86.7%。两组患者术后AHI、LSaO2及内皮素-1（ET-1）与术前比较差异有统计学意义。AHI与LSaO2、LSaO2与ET-1之间呈负相关。