Yang Lei, Hu Yingjie, Zhang Xiaowen
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Jun;26(12):569-72.
Obstructive sleep apnea syndrome (OSAS) is endangering human health seriously now. We had reviewed some typical animal model which had at least one OSAS character of intermittent hypoxia and/or hypercapnia, upper airway obstruction and sleep structure disorder. However, all of these models could not simulate clinical and pathological features of OSAS completely. Establishing a suitable animal model to study OSAS and related diseases is very important.
阻塞性睡眠呼吸暂停低通气综合征（OSAS）目前正严重危害人类健康。我们回顾了一些典型的动物模型，这些模型至少具有间歇性缺氧和/或高碳酸血症、上气道阻塞以及睡眠结构紊乱等OSAS特征中的一种。然而，所有这些模型都不能完全模拟OSAS的临床和病理特征。建立合适的动物模型来研究OSAS及相关疾病非常重要。
