Ma Liang, Zhang Wen, Tang Jinsong, Tan Liwen, Yao Yong-Gang, Chen Xiaogang
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan.
Psychiatr Genet. 2013 Feb;23(1):29-32. doi: 10.1097/YPG.0b013e32835862c5.
Accumulating evidence suggests that mitochondrial dysfunction contributes toward the pathogenesis of psychiatric diseases. NADH dehydrogenase Fe-S protein 7 (NDUFS7), a subunit of respiratory chain complex I, has been reported recently to be associated with bipolar disorder. To test whether this gene can confer a wide variety of psychiatric disorders, we carried out a case-control association analysis of three tagging single-nucleotide polymorphisms (rs2074896, rs2074897, and rs2074898) in the NDUFS7 gene by sequencing 330 Han Chinese patients with schizophrenia and 330 well-matched healthy controls. We found no significant difference in the frequency distributions of alleles, genotypes, and haplotypes between the cases and the controls, indicating no active role of this gene in schizophrenia.
越来越多的证据表明，线粒体功能障碍在精神疾病的发病机制中起作用。呼吸链复合体I的一个亚基NADH脱氢酶铁硫蛋白7（NDUFS7）最近被报道与双相情感障碍有关。为了测试该基因是否会导致多种精神疾病，我们对330例汉族精神分裂症患者和330例匹配良好的健康对照进行测序，对NDUFS7基因中的三个标签单核苷酸多态性（rs2074896、rs2074897和rs2074898）进行了病例对照关联分析。我们发现病例组和对照组之间的等位基因、基因型和单倍型频率分布没有显著差异，表明该基因在精神分裂症中没有起作用。
