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ANDVisio:一种用于图形可视化和分析AND系统中挖掘的文献关联基因网络的新工具。

ANDVisio: a new tool for graphic visualization and analysis of literature mined associative gene networks in the ANDSystem.

作者信息

Demenkov P S, Ivanisenko T V, Kolchanov N A, Ivanisenko V A

机构信息

Computer Proteomics Laboratory, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.

出版信息

In Silico Biol. 2011;11(3-4):149-61. doi: 10.3233/ISB-2012-0449.

Abstract

The ANDVisio tool is designed to reconstruct and analyze associative gene networks in the earlier developed Associative Network Discovery System (ANDSystem) software package. The ANDSystem incorporates utilities for automated extraction of knowledge from Pubmed published scientific texts, analysis of factographic databases, also the ANDCell database containing information on molecular-genetic events retrieved from texts and databases. ANDVisio is a new user's interface to the ANDCell database stored in a remote server. ANDVisio provides graphic visualization, editing, search, also saving of associative gene networks in different formats resulting from user's request. The associative gene networks describe semantic relationships between molecular-genetic objects (proteins, genes, metabolites and others), biological processes, and diseases. ANDVisio is provided with various tools to support filtering by object types, relationships between objects and information sources; graph layout; search of the shortest pathway; cycles in graphs.

摘要

ANDVisio工具旨在重建和分析早期开发的关联网络发现系统(ANDSystem)软件包中的关联基因网络。ANDSystem包含从PubMed发表的科学文本中自动提取知识的实用程序、事实数据库分析程序,以及ANDCell数据库,该数据库包含从文本和数据库中检索到的分子遗传事件信息。ANDVisio是存储在远程服务器中的ANDCell数据库的新用户界面。ANDVisio提供图形可视化、编辑、搜索功能,还能以用户要求的不同格式保存关联基因网络。关联基因网络描述了分子遗传对象(蛋白质、基因、代谢物等)、生物过程和疾病之间的语义关系。ANDVisio配备了各种工具,以支持按对象类型、对象之间的关系和信息源进行过滤;图形布局;最短路径搜索;图中的循环。

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