Monash University Alfred Campus, Alfred Centre, 99 Commercial Road, Melbourne, Vic 3004, Australia.
Pathology. 2012 Oct;44(6):513-8. doi: 10.1097/PAT.0b013e3283581780.
To assess the prognostic utility of semi-quantiative expression of RhoC protein in whole prostates from patients who had radical prostatectomies for high grade prostate cancer (PCa).
Subjects who had surgery >55 months previously with primary Gleason pattern 4 PCa were identified from practice records, archival tissues were retrieved for review and RhoC immunohistochemistry, and ZAG expression was also assessed as a control.
Eighty-nine subjects were included in the study; 57 had a rising prostate specific antigen (PSA) post-operatively ('cases') and 32 did not ('controls'). By univariate analysis, expression of both RhoC and ZAG proteins was greater in controls than cases, but this was significant only for ZAG. By multivariate analysis, Gleason variables (patterns and score), extraprostatic extension and decreased RhoC staining all contributed to predicting PSA failure (p < 0.05). ZAG expression was inversely correlated with Gleason pattern and hence was not independently predictive in our multivariate model.
Increased RhoC expression predicted a good outcome after radical prostatectomy. ZAG staining also correlated with a favourable outcome but was not independently predictive due to its relationship with Gleason pattern.
评估 RhoC 蛋白在接受根治性前列腺切除术的高分级前列腺癌（PCa）患者整个前列腺中的半定量表达的预后价值。
从实践记录中确定了 55 个月前接受过原发性 Gleason 模式 4 PCa 手术的患者，从存档组织中提取 RhoC 免疫组织化学和 ZAG 表达进行评估作为对照。
本研究共纳入 89 例患者；57 例术后前列腺特异性抗原（PSA）升高（“病例”），32 例未升高（“对照”）。单因素分析显示，对照组 RhoC 和 ZAG 蛋白的表达均高于病例组，但仅 ZAG 蛋白表达具有统计学意义。多因素分析显示，Gleason 变量（模式和评分）、前列腺外延伸和 RhoC 染色减少均有助于预测 PSA 失败（p < 0.05）。ZAG 表达与 Gleason 模式呈负相关，因此在我们的多变量模型中不具有独立预测性。
RhoC 表达增加预示着根治性前列腺切除术后的良好预后。ZAG 染色也与良好的预后相关，但由于与 Gleason 模式的关系，不具有独立的预测性。
