Wong David M, Moore Rustin M, Brockus Charles W
Iowa State University, Ames, IA, USA.
Compend Contin Educ Vet. 2012 Aug;34(8):E5.
This article discusses the potential role of oxidative injury to the intestinal tract of horses and the therapeutic approaches that have been investigated to decrease cellular damage secondary to ischemia-reperfusion (IR) injury. Equine colic is a major concern for horse owners and veterinary practitioners. Strangulating and obstructive lesions of the small and large intestines commonly require intervention in patients via exploratory celiotomy. However, the application of information from experimentally induced IR injury in horses to clinical cases of naturally occurring equine colic is not clear. Thus, while the exact mechanisms and clinical significance of intestinal IR are being defined and may be matters of academic debate, a review of the available information may provide knowledge of potential underlying pathophysiologic mechanisms contributing to intestinal injury in equine colic. This information may allow clinicians to offer additional therapeutic strategies for horses with strangulating obstruction of the small or large intestine. Further clinical study of the therapeutic options for horses with naturally occurring disease is warranted.
本文讨论了氧化损伤对马肠道的潜在作用，以及为减少缺血再灌注（IR）损伤继发的细胞损伤而进行研究的治疗方法。马的急腹症是马主和兽医从业者主要关注的问题。小肠和大肠的绞窄性和阻塞性病变通常需要通过剖腹探查术对患者进行干预。然而，将马实验性诱导的IR损伤信息应用于自然发生的马急腹症临床病例尚不清楚。因此，虽然肠道IR的确切机制和临床意义正在被界定，可能是学术争论的问题，但对现有信息的回顾可能会提供有助于马急腹症肠道损伤的潜在病理生理机制的知识。这些信息可能使临床医生为患有小肠或大肠绞窄性梗阻的马提供额外的治疗策略。对患有自然疾病的马的治疗选择进行进一步的临床研究是必要的。
