Goettler D M, Levin L, Chey W Y
Nutrition Department, London Regional Cancer Centre, ON, Canada.
J Natl Cancer Inst. 1990 Jan 3;82(1):22-9. doi: 10.1093/jnci/82.1.22.
Previous studies of the relationship between dietary fat and breast cancer have produced conflicting results and have provided no definitive evidence of a mechanistic link between fat and breast tumorigenesis. We conducted a study to compare postprandial levels of prolactin (Prl), a hormone suspected of promoting the growth of some human breast cancer, and several gut hormones, i.e., gastrin (Gs), vasoactive intestinal polypeptide (VIP), neurotensin (Nt), and cholecystokinin (CCK), following high- and low-fat isocaloric test meals. Data were obtained in the posttreatment period from 13 patients with breast cancer (nine stage I and four stage II), who were disease free clinically, and nine healthy controls. Subjects admitted to the research unit on 2 days were given the high-fat meal on day 1 and the low-fat meal on day 2. Blood samples were drawn before (i.e., fasting) and after test meal consumption. All hormone analyses were performed by radioimmunoassay. Results indicated a significant rise in postprandial Prl levels for stage II patients, but not for stage I patients or the controls. Postprandial Gs levels were also elevated, whereas VIP levels were markedly reduced in patients versus controls; these differences were most marked in stage II patients. No significant intergroup differences were noted in postprandial levels of Nt and CCK. Hormone levels of patients and controls did not differ between the test meal situations, which indicated that some other component of the test meals might have been responsible for altered Prl and Gs levels. The differences observed between the stage I and II patients indicated that diet may influence the aggressiveness of tumor behavior and development through alterations in postprandial hormone release.
先前关于膳食脂肪与乳腺癌之间关系的研究结果相互矛盾，且未提供脂肪与乳腺肿瘤发生之间存在机制联系的确切证据。我们开展了一项研究，比较了高脂肪和低脂肪等热量试验餐后催乳素（Prl，一种被怀疑会促进某些人类乳腺癌生长的激素）以及几种肠道激素（即胃泌素（Gs）、血管活性肠肽（VIP）、神经降压素（Nt）和胆囊收缩素（CCK））的餐后水平。在治疗后阶段，从13例临床无疾病的乳腺癌患者（9例I期和4例II期）和9名健康对照者中获取数据。入选研究单位2天的受试者在第1天给予高脂肪餐，在第2天给予低脂肪餐。在试验餐食用前（即空腹时）和食用后采集血样。所有激素分析均采用放射免疫测定法进行。结果表明，II期患者餐后Prl水平显著升高，而I期患者或对照者则未出现这种情况。餐后Gs水平也有所升高，而患者的VIP水平与对照者相比明显降低；这些差异在II期患者中最为明显。餐后Nt和CCK水平在组间未观察到显著差异。患者和对照者的激素水平在试验餐情况下没有差异，这表明试验餐的其他某些成分可能是导致Prl和Gs水平改变的原因。I期和II期患者之间观察到的差异表明，饮食可能通过改变餐后激素释放来影响肿瘤行为和发展的侵袭性。
