Momani Munther S, Al Tarawni Ahmad, Momani Yazan M, Rahhal Sara, Elhaj Ibrahim, Al-Halhouli Dania, Alhawari Hussam
Internal Medicine Department, School of Medicine, University of Jordan, Queen Rania Street, Amman 11942, Jordan.
School of Medicine, University of Jordan, Queen Rania Street, Amman 11942, Jordan.
J Pers Med. 2024 Aug 27;14(9):905. doi: 10.3390/jpm14090905.
The objective of this study was to investigate the effect of age, gender, body mass index (BMI), food intake, and smoking on serum prolactin (PRL) levels among healthy adults.
In total, 100 healthy adults (46 males and 54 females) aged ≥18 years were recruited. Serum PRL levels were measured after a 9 h overnight fast, 1 h postprandially (early), and 3 h postprandially (late).
Mean PRL levels were significantly higher in females than males in the fasting, early, and late postprandial states. PRL levels were suppressed significantly after food intake in both genders. Mean PRL levels were significantly higher in younger individuals (<30 years) in the fasting and the early postprandial states compared to older individuals (≥30 years) and suppressed significantly after food intake in younger individuals only. Mean PRL levels were not significantly different between individuals with a normal BMI (<25 kg/m) compared to those overweight and with obesity (BMI ≥ 25 kg/m); however, PRL levels were significantly suppressed after food intake only in subjects with a normal BMI. Mean PRL levels did not differ significantly according to smoking status. PRL levels were suppressed significantly after food intake in nonsmokers only.
Our data suggest that age, gender, and food intake should be considered when the serum PRL level is measured in clinical practice.
本研究旨在调查年龄、性别、体重指数（BMI）、食物摄入量和吸烟对健康成年人血清催乳素（PRL）水平的影响。
共招募了100名年龄≥18岁的健康成年人（46名男性和54名女性）。在禁食9小时后、餐后1小时（早期）和餐后3小时（晚期）测量血清PRL水平。
在禁食、餐后早期和晚期状态下，女性的平均PRL水平显著高于男性。两性在进食后PRL水平均显著降低。在禁食和餐后早期状态下，较年轻个体（<30岁）的平均PRL水平显著高于较年长个体（≥30岁），且仅较年轻个体在进食后PRL水平显著降低。体重指数正常（<25kg/m）的个体与超重和肥胖个体（BMI≥25kg/m）之间的平均PRL水平无显著差异；然而，仅体重指数正常的受试者在进食后PRL水平显著降低。平均PRL水平根据吸烟状况无显著差异。仅非吸烟者在进食后PRL水平显著降低。
我们的数据表明，在临床实践中测量血清PRL水平时应考虑年龄、性别和食物摄入量。
