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Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.

作者信息

Bae Harold T, Baldwin Clinton T, Sebastiani Paola, Telen Marilyn J, Ashley-Koch Allison, Garrett Melanie, Hooper W Craig, Bean Christopher J, Debaun Michael R, Arking Dan E, Bhatnagar Pallav, Casella James F, Keefer Jeffrey Renn, Barron-Casella Emily, Gordeuk Victor, Kato Gregory J, Minniti Caterina, Taylor James, Campbell Andrew, Luchtman-Jones Lori, Hoppe Carolyn, Gladwin Mark T, Zhang Yingze, Steinberg Martin H

出版信息

Blood. 2012 Aug 30;120(9):1961-2. doi: 10.1182/blood-2012-06-432849.

DOI:10.1182/blood-2012-06-432849
PMID:22936743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3433099/
Abstract
摘要

相似文献

1
Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.对2040例镰状细胞贫血患者的荟萃分析:在非裔美国人中,BCL11A和HBS1L-MYB是胎儿血红蛋白(HbF)的主要调节因子。
Blood. 2012 Aug 30;120(9):1961-2. doi: 10.1182/blood-2012-06-432849.
2
Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.喀麦隆镰状细胞病患者中BCL11A和HBS1L-MYB基因变异与胎儿血红蛋白及住院率的关联
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3
Genotyping of BCL11A and HBS1L-MYB SNPs associated with fetal haemoglobin levels: a SNaPshot minisequencing approach.采用 SNaPshot 微测序法对与胎儿血红蛋白水平相关的 BCL11A 和 HBS1L-MYB SNPs 进行基因分型。
BMC Genomics. 2014 Feb 6;15:108. doi: 10.1186/1471-2164-15-108.
4
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.BCL11A、HBS1L-MYB和β-珠蛋白基因座的DNA多态性与镰状细胞病中的胎儿血红蛋白水平和疼痛危象相关。
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Protective BCL11A and HBS1L-MYB polymorphisms in a cohort of 102 Congolese patients suffering from sickle cell anemia.102名患有镰状细胞贫血的刚果患者队列中的保护性BCL11A和HBS1L-MYB基因多态性
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Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients.BCL11A、HSB1L-MYB 和 XmnI γG-158(C/T)基因多态性与埃及镰状细胞病患者血红蛋白 F 水平的关联。
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BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.BCL11A是三种不同β-血红蛋白病患者群体中的一个主要胎儿血红蛋白(HbF)数量性状位点。
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Haplotype-Resolved Genotyping and Association Analysis of 1,020 β-Thalassemia Patients by Targeted Long-Read Sequencing.通过靶向长读长测序对1020例β地中海贫血患者进行单倍型解析基因分型和关联分析
Adv Sci (Weinh). 2025 Mar;12(9):e2410992. doi: 10.1002/advs.202410992. Epub 2024 Dec 31.
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Prevalence and Impact of HMOX1 Polymorphism (rs2071746: A > T) in Indian Sickle Cell Disease Patients.印度镰状细胞病患者中HMOX1基因多态性(rs2071746:A > T)的患病率及影响
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本文引用的文献

1
Genetic modifiers of sickle cell disease.镰状细胞病的遗传修饰物。
Am J Hematol. 2012 Aug;87(8):795-803. doi: 10.1002/ajh.23232. Epub 2012 May 28.
2
Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence.用于全基因组关联研究荟萃分析的方法:对经验证据的批判性评估。
Am J Epidemiol. 2012 Apr 15;175(8):739-49. doi: 10.1093/aje/kwr385. Epub 2012 Mar 16.
3
Fetal hemoglobin in sickle cell anemia.镰状细胞贫血中的胎儿血红蛋白。
Blood. 2011 Jul 7;118(1):19-27. doi: 10.1182/blood-2011-03-325258. Epub 2011 Apr 13.
4
Missing heritability and strategies for finding the underlying causes of complex disease.复杂疾病遗传率缺失及其潜在病因的研究策略。
Nat Rev Genet. 2010 Jun;11(6):446-50. doi: 10.1038/nrg2809.
5
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.镰状细胞贫血中的胎儿血红蛋白:全基因组关联研究提示 5'嗅觉受体基因簇中的一个调节区域。
Blood. 2010 Mar 4;115(9):1815-22. doi: 10.1182/blood-2009-08-239517. Epub 2009 Dec 16.
6
The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells.与血红蛋白F(HbF)水平升高相关的HBS1L-MYB基因间间隔在红系细胞中显示出远端调控区域的特征。
Blood. 2009 Aug 6;114(6):1254-62. doi: 10.1182/blood-2009-03-210146. Epub 2009 Jun 15.