Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.
作者信息
Bae Harold T, Baldwin Clinton T, Sebastiani Paola, Telen Marilyn J, Ashley-Koch Allison, Garrett Melanie, Hooper W Craig, Bean Christopher J, Debaun Michael R, Arking Dan E, Bhatnagar Pallav, Casella James F, Keefer Jeffrey Renn, Barron-Casella Emily, Gordeuk Victor, Kato Gregory J, Minniti Caterina, Taylor James, Campbell Andrew, Luchtman-Jones Lori, Hoppe Carolyn, Gladwin Mark T, Zhang Yingze, Steinberg Martin H
出版信息
Blood. 2012 Aug 30;120(9):1961-2. doi: 10.1182/blood-2012-06-432849.
Abstract
摘要
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Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans.对2040例镰状细胞贫血患者的荟萃分析：在非裔美国人中，BCL11A和HBS1L-MYB是胎儿血红蛋白（HbF）的主要调节因子。
Blood. 2012 Aug 30;120(9):1961-2. doi: 10.1182/blood-2012-06-432849.
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本文引用的文献
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Genetic modifiers of sickle cell disease.镰状细胞病的遗传修饰物。
Am J Hematol. 2012 Aug;87(8):795-803. doi: 10.1002/ajh.23232. Epub 2012 May 28.
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Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence.用于全基因组关联研究荟萃分析的方法：对经验证据的批判性评估。
Am J Epidemiol. 2012 Apr 15;175(8):739-49. doi: 10.1093/aje/kwr385. Epub 2012 Mar 16.
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Fetal hemoglobin in sickle cell anemia.镰状细胞贫血中的胎儿血红蛋白。
Blood. 2011 Jul 7;118(1):19-27. doi: 10.1182/blood-2011-03-325258. Epub 2011 Apr 13.
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Missing heritability and strategies for finding the underlying causes of complex disease.复杂疾病遗传率缺失及其潜在病因的研究策略。
Nat Rev Genet. 2010 Jun;11(6):446-50. doi: 10.1038/nrg2809.
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Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.镰状细胞贫血中的胎儿血红蛋白：全基因组关联研究提示 5'嗅觉受体基因簇中的一个调节区域。
Blood. 2010 Mar 4;115(9):1815-22. doi: 10.1182/blood-2009-08-239517. Epub 2009 Dec 16.
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The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells.与血红蛋白F（HbF）水平升高相关的HBS1L-MYB基因间间隔在红系细胞中显示出远端调控区域的特征。
Blood. 2009 Aug 6;114(6):1254-62. doi: 10.1182/blood-2009-03-210146. Epub 2009 Jun 15.
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