第二代抗精神病药物可改善精神分裂症患者的性功能障碍：一项随机对照试验。
Second generation antipsychotics improve sexual dysfunction in schizophrenia: a randomised controlled trial.
作者信息
Mahmoud Ahmed, Hayhurst Karen P, Drake Richard J, Lewis Shôn W
机构信息
Mental Health and Neurodegeneration Research Group, The University of Manchester, Manchester M13 9PL, UK.
出版信息
Schizophr Res Treatment. 2011;2011:596898. doi: 10.1155/2011/596898. Epub 2011 Jan 16.
Abstract
The impact of antipsychotic drug treatment on sexual function was investigated during a randomised trial comparing first generation antipsychotics (FGAs) to (nonclozapine) second generation antipsychotics (SGAs). Sexual function and quality of life were (rater-blind) assessed in 42 patients with DSM-IV schizophrenia (aged 18-65) using the self-report version of the Derogatis Interview for Sexual Function (DISF-SR) and the Heinrichs Quality of Life Scale (QLS), prior to, and 12 weeks following, a change in medication from an FGA drug to either an FGA or SGA drug. SGAs significantly improved sexual function compared to FGAs. Change in sexual function was associated with change in quality of life. Where impaired sexual functioning is a distressing adverse effect of treatment with an FGA agent, consideration should be given to switching to an SGA.
摘要
在一项将第一代抗精神病药物（FGAs）与（非氯氮平）第二代抗精神病药物（SGAs）进行比较的随机试验中，研究了抗精神病药物治疗对性功能的影响。在42名符合《精神疾病诊断与统计手册》第四版（DSM-IV）标准的精神分裂症患者（年龄在18至65岁之间）中，在从FGA药物换用FGA或SGA药物之前以及用药12周后，使用Derogatis性功能访谈自评版（DISF-SR）和海因里希斯生活质量量表（QLS）对性功能和生活质量进行了（评估者盲法）评估。与FGAs相比，SGAs显著改善了性功能。性功能的变化与生活质量的变化相关。如果性功能受损是FGA药物治疗令人苦恼的不良反应，则应考虑换用SGA。
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