范可尼贫血和T细胞急性淋巴细胞白血病的成功治疗。
Successful treatment of fanconi anemia and T-cell acute lymphoblastic leukemia.
作者信息
Flatt Terrie, Neville Kathleen, Lewing Karen, Dalal Jignesh
机构信息
Division of Hematology/Oncology, Department of Pediatrics, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA.
出版信息
Case Rep Hematol. 2012;2012:396395. doi: 10.1155/2012/396395. Epub 2012 Apr 1.
Abstract
Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. Now 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia.
摘要
范可尼贫血与恶性肿瘤风险增加相关。患者对化疗的毒性作用敏感。我们报告了一例患有范可尼贫血并发展为T细胞急性淋巴细胞白血病的患者。他经历了化疗相关并发症，包括长期中性粒细胞减少、IV级长春新碱神经病变和播散性曲霉病。他通过调整阿糖胞苷剂量和鞘内注射甲氨蝶呤成功治疗，随后接受了异基因骨髓移植。曲霉病采用全身抗真菌治疗和手术切除。骨髓移植30个月后，患者目前没有曲霉病或白血病的迹象。
相似文献
1
Successful treatment of fanconi anemia and T-cell acute lymphoblastic leukemia.
Case Rep Hematol. 2012;2012:396395. doi: 10.1155/2012/396395. Epub 2012 Apr 1.
2
Double Philadelphia chromosome-positive B acute lymphoblastic leukaemia in an elderly patient.
Malays J Pathol. 2015 Dec;37(3):275-9.
3
Hematopoietic Stem Cell Transplant in Adolescent and Young Adults With Fanconi Anemia Is Feasible With Acceptable Toxicity, With Those Surviving 100 Days Posttransplant Having Excellent Outcomes.
Exp Clin Transplant. 2016 Dec;14(6):660-664. doi: 10.6002/ect.2015.0364. Epub 2016 Jul 22.
4
Fanconi anemia with biallelic FANCD1/BRCA2 mutations - Case report of a family with three affected children.
Eur J Med Genet. 2016 Mar;59(3):152-7. doi: 10.1016/j.ejmg.2015.11.013. Epub 2015 Dec 2.
5
Invasive aspergillosis in haematological malignancies: clinical findings and management for intensive chemotherapy completion.
Am J Hematol. 2001 Dec;68(4):231-6. doi: 10.1002/ajh.1187.
6
The role of systemic high-dose cytarabine in the treatment of central nervous system leukemia. Clinical results in 46 patients.
Cancer. 1993 Jul 15;72(2):439-45. doi: 10.1002/1097-0142(19930715)72:2<439::aid-cncr2820720220>3.0.co;2-4.
7
Precursor-T lymphoblastic lymphoma after unrelated bone marrow transplantation in a patient with Fanconi anemia.
J Pediatr Hematol Oncol. 2011 Jan;33(1):22-4. doi: 10.1097/MPH.0b013e3181eb3153.
8
Novel multiagent chemotherapy for bone marrow relapse of pediatric acute lymphoblastic leukemia.
Med Pediatr Oncol. 2000 May;34(5):313-8. doi: 10.1002/(sici)1096-911x(200005)34:5<313::aid-mpo1>3.0.co;2-q.
9
Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial.
J Clin Oncol. 2001 Apr 1;19(7):1935-42. doi: 10.1200/JCO.2001.19.7.1935.
10
Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry.
Haematologica. 2008 Apr;93(4):511-7. doi: 10.3324/haematol.12234. Epub 2008 Mar 5.
引用本文的文献
1
Management of Fanconi anemia beyond childhood.
Hematology Am Soc Hematol Educ Program. 2023 Dec 8;2023(1):556-562. doi: 10.1182/hematology.2023000489.
2
A Systematic Review to Assess the Relationship between Disseminated Cerebral Aspergillosis, Leukemias and Lymphomas, and Their Respective Therapeutics.
J Fungi (Basel). 2022 Jul 11;8(7):722. doi: 10.3390/jof8070722.
3
Leukemia growth is inhibited by benzoxime without causing any harmful effect in rats bearing RBL-1 ×enotransplants.
Oncol Lett. 2019 Feb;17(2):1934-1938. doi: 10.3892/ol.2018.9783. Epub 2018 Nov 30.
4
Haematopoietic cell transplantation for acute leukaemia and advanced myelodysplastic syndrome in Fanconi anaemia.
Br J Haematol. 2014 Feb;164(3):384-95. doi: 10.1111/bjh.12634. Epub 2013 Oct 30.
5
In vivo evaluation of the synthesized novel 2-benzyloxybenzaldehyde analog CCY-1a-E2 for the treatment of leukemia in the BALB/c mouse WEHI-3 allograft model.
Oncol Lett. 2013 Mar;5(3):777-782. doi: 10.3892/ol.2012.1079. Epub 2012 Dec 17.
本文引用的文献
1
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity.
Cancer Chemother Pharmacol. 2008 Nov;62(6):995-1007. doi: 10.1007/s00280-008-0689-7. Epub 2008 Feb 13.
2
Successful combination of antifungal agents and surgical resection for pulmonary aspergillosis in a child with Hodgkin disease: review of the literature.
Pediatr Hematol Oncol. 2007 Dec;24(8):631-8. doi: 10.1080/08880010701620988.
3
Aberrant activation of stress-response pathways leads to TNF-alpha oversecretion in Fanconi anemia.
Blood. 2008 Feb 15;111(4):1913-23. doi: 10.1182/blood-2007-07-099218. Epub 2007 Nov 30.
4
Central nervous system aspergillosis in children: a systematic review of reported cases.
Int J Infect Dis. 2007 Sep;11(5):381-93. doi: 10.1016/j.ijid.2007.01.013. Epub 2007 May 16.
5
In vitro effect of fludarabine, cyclophosphamide, and cytosine arabinoside on chromosome breakage in Fanconi anemia patients: relevance to stem cell transplantation.
Int J Hematol. 2007 May;85(4):354-61. doi: 10.1532/IJH97.06191.
6
A novel Leu153Ser mutation of the Fanconi anemia FANCD2 gene is associated with severe chemotherapy toxicity in a pediatric T-cell acute lymphoblastic leukemia.
Leukemia. 2007 Jan;21(1):72-8. doi: 10.1038/sj.leu.2404468. Epub 2006 Nov 9.
7
Chemotherapy for myeloid malignancy in children with Fanconi anemia.
Pediatr Blood Cancer. 2007 Jun 15;48(7):668-72. doi: 10.1002/pbc.20843.
8
Improved survival in central nervous system aspergillosis: a series of immunocompromised children with leukemia undergoing stereotactic resection of aspergillomas. Report of four cases.
J Neurosurg. 2005 Oct;103(4 Suppl):374-8. doi: 10.3171/ped.2005.103.4.0374.
9
Improved outcome in central nervous system aspergillosis, using voriconazole treatment.
Blood. 2005 Oct 15;106(8):2641-5. doi: 10.1182/blood-2005-02-0733. Epub 2005 Jul 5.
10
Invasive aspergillosis before allogeneic hematopoietic stem cell transplantation: 10-year experience at a single transplant center.
Biol Blood Marrow Transplant. 2004 Jul;10(7):494-503. doi: 10.1016/j.bbmt.2004.02.006.
Zotero 插件