Department of Chemistry, Indian Institute of Technology Madras, Chennai, India.
Analyst. 2012 Oct 21;137(20):4795-801. doi: 10.1039/c2an35964b.
This investigation, following our recent report on the one-pot hemi-micellar interfacial synthesis of Janus gold nanoclusters and the inter-cluster electron coupling establishing insulator-metal transition in the oriented Janus monolayers [Langmuir, 2010, 26(17), 14047], was to fabricate modified electrodes for sensing dopamine, the neurotransmitter. With a detection limit in the sub-nanomolar range, the apparent electron transfer rate constants for dopamine detection signified an intricate Janus cluster 2D phase dependency. Surface pressure as a thermodynamic variable controlled the electronic communication between the clusters as a result of varied inter-cluster distance and size, ultimately reflecting on the sensitivity and detection limit for dopamine sensing. The non-covalent nature of the ligands on the core metal clusters facilitated the overall electro-catalytic oxidation of dopamine. The notable feature of this precise work was that it established a more effective phase- and orientation-specific Janus cluster sensing than those reported through patterned gold nanowire based sensors.
本研究在我们最近关于一锅法介观界面合成金 Janus 纳米簇以及在定向 Janus 单层中建立电子耦合实现绝缘-金属转变的报道[Langmuir, 2010, 26(17), 14047]之后，旨在制备用于检测神经递质多巴胺的修饰电极。该修饰电极具有亚纳摩尔级的检测限，检测多巴胺的表观电子转移速率常数表明 Janus 纳米簇 2D 相依赖性非常复杂。表面压力作为热力学变量控制了电子在纳米簇之间的传递，这是由于纳米簇之间的距离和大小发生了变化，最终反映了对多巴胺检测的灵敏度和检测限。核心金属纳米簇上配体的非共价性质促进了多巴胺的整体电催化氧化。这项精确工作的显著特点是，它建立了一种比基于金纳米线图案传感器报道的更有效、更具相和定向特异性的 Janus 纳米簇传感器。
