多种美容成分血清在改善衰老皮肤面部红斑中的临床疗效。

Clinical efficacy of a serum integrating multiple cosmetic ingredients in the management of erythema of the face in aging skin.

机构信息

Immanence Integral Dermo Correction, Quebec, Quebec, Canada.

出版信息

J Cosmet Dermatol. 2012 Sep;11(3):207-12. doi: 10.1111/j.1473-2165.2012.00623.x.

DOI:10.1111/j.1473-2165.2012.00623.x

PMID:22938005

Abstract

BACKGROUND

Skin redness is a common cosmetic concern affecting predominantly fair-skin individuals and often leading to rosacea. On the basis of the current scientific knowledge of the physiological mechanisms underlying the problem, a complex and integral skin care serum (100RXED2025) was developed and tested clinically for efficacy.

METHOD

Forty-five healthy men and women volunteers, age 30-65, were recruited. All subjects had fair skin (phototype I, II, or III) and presented some degree of skin redness with telangiectasia on the cheeks, the nose, or the nose sides, at baseline. In the course of this open label study, subjects applied the test product on their face, twice daily for 56 days. For each subject, skin redness was evaluated through colorimetric and visual analysis of photographs taken under cross-polarized light at T = 28 (week 4) and T = 56 (week 8), then compared to baseline measurements obtained at day 0.

RESULTS

Forty-four volunteers completed the study. On visual evaluation, skin redness had decreased in average by 32.2% at T = 28 (P < 0.001) and by 48.0% at T = 56 (P < 0.001). Importantly, 91% of the subjects showed improvement of skin redness at T = 28, reaching 100% at T = 56. Colorimetric analysis gave an average reduction in redness of 11.6% at T = 28 (P < 0.001) and 13.7% at T = 56 (P < 0.001).

CONCLUSION

The anti-redness efficacy of the test product was demonstrated after 28 days with further increase following 56 days of application.

摘要

背景

皮肤泛红是一种常见的美容问题，主要影响肤色较浅的人群，常导致酒渣鼻。基于目前对该问题生理机制的科学认识，开发并临床测试了一种复杂的综合性皮肤护理精华液（100RXED2025）以评估其功效。

方法

招募了 45 名年龄在 30-65 岁之间的健康男性和女性志愿者。所有受试者均为浅肤色（肤色类型 I、II 或 III），且在基线时脸颊、鼻子或鼻子两侧存在一定程度的皮肤泛红和毛细血管扩张。在这项开放性标签研究中，受试者在面部每天涂抹两次测试产品，共 56 天。对于每个受试者，在 T = 28（第 4 周）和 T = 56（第 8 周）时，通过对偏振光下拍摄的照片进行比色和视觉分析来评估皮肤泛红，并与在第 0 天获得的基线测量值进行比较。

结果

44 名志愿者完成了这项研究。在视觉评估中，皮肤泛红在 T = 28 时平均减少了 32.2%（P < 0.001），在 T = 56 时减少了 48.0%（P < 0.001）。重要的是，91%的受试者在 T = 28 时皮肤泛红得到改善，在 T = 56 时达到 100%。比色分析显示，在 T = 28 时，皮肤泛红的平均减少了 11.6%（P < 0.001），在 T = 56 时减少了 13.7%（P < 0.001）。