胆囊癌：132例预后因素分析
Gallbladder carcinoma: analysis of prognostic factors in 132 cases.
作者信息
Wang Rui-Tao, Xu Xin-Sen, Liu Jun, Liu Chang
机构信息
Department of hepatobiliary surgery, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
出版信息
Asian Pac J Cancer Prev. 2012;13(6):2511-4. doi: 10.7314/apjcp.2012.13.6.2511.
OBJECTIVE
To evaluate the prognostic factors of gallbladder carcinoma.
METHODS
Presentation, operative data, complications, and survival outcome were examined for 132 gallbladder carcinoma patients who underwent gallbladder surgery in our unit during 2002-2007, and follow-up results were obtained from every patient for univariate and multivariate survival analysis.
RESULTS
The univariate analysis showed that gallbladder lesion history, tumor cell differentiation, Nevin staging, preoperative lymph node metastasis and the surgical approach significantly correlated with the prognosis of the patients (p <0.05). The results of the multivariate analysis (Cox regression) showed that gallbladder lesion history, Nevin staging and the surgical approach were independent predicators with relative risks of 6.9, 4.4, 2.8, respectively (p=0.002, 0.003, 0.008).
CONCLUSION
Gallbladder lesion history, Nevin staging and the surgical approach are independent prognostic factors for gallbladder carcinoma, a rapidly fatal disease. Therefore, early diagnosis, anti-infective therapy and radical surgery are greatly needed to improve the prognosis of gallbladder carcinoma.
目的
评估胆囊癌的预后因素。
方法
对2002年至2007年期间在本单位接受胆囊手术的132例胆囊癌患者的临床表现、手术数据、并发症及生存结果进行检查，并从每位患者获取随访结果以进行单因素和多因素生存分析。
结果
单因素分析显示，胆囊病变史、肿瘤细胞分化、Nevin分期、术前淋巴结转移及手术方式与患者预后显著相关（p<0.05）。多因素分析（Cox回归）结果显示，胆囊病变史、Nevin分期及手术方式为独立预测因素，相对风险分别为6.9、4.4、2.8（p=0.002、0.003、0.008）。
结论
胆囊病变史、Nevin分期及手术方式是胆囊癌（一种快速致死性疾病）的独立预后因素。因此，急需早期诊断、抗感染治疗及根治性手术以改善胆囊癌的预后。
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