Lu Min, Sun Luhaoran, Yang Jing, Li Yue-Yao
Department of Colorectal Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China.
Asian Pac J Cancer Prev. 2012;13(6):2605-10. doi: 10.7314/apjcp.2012.13.6.2605.
Studies investigating the association of 2R/3R polymorphism in the thymidylate synthase 5'-untranslated enhanced region (TSER) and colorectal cancer (CRC) risk have reported conflicting results. Thus, a meta-analysis was performed to summarize the data on the potential association.
Pubmed, Embase and CBM databases were searched for all available studies. Links between the TSER 2R/3R polymorphism and CRC risk were estimated by odds ratios (ORs) with 95% confidence intervals (CIs).
Seven case-control studies with a total of 2723 cases and 4030 controls were included in this meta-analysis. The results showed that the 3R variant of TSER 2R/3R polymorphism contributes to CRC risk in two comparison models (OR 3R vs. 2R =1.10, 95%CI 1.02-1.18, P = 0.015; OR Homozygote comparison model = 1.22 1.04-1.43, 95%CI 1.04- 1.43, P = 0.012). Subgroup analyses by ethnicity further demonstrated a contribution in Caucasians with three comparison models (OR 3R vs. 2R = 1.10, 95%CI 1.02-1.19, P = 0.015; OR Homozygote comparison model = 1.21, 95%CI 1.03-1.41, P = 0.019; OR Recessive comparison model = 1.18, 95%CI 1.05-1.33, P = 0.008). However, the association in the Asian population was still uncertain due to the limited data (all P values were more than 0.05).
Our meta-analysis suggests that the 3R variant of Thymidylate synthase 5'-untranslated enhanced region 2R/3R polymorphism contributes to gastric cancer risk in the Caucasian population, while any association in Asian populations needs further study.
关于胸苷酸合成酶5'-非翻译增强区（TSER）的2R/3R多态性与结直肠癌（CRC）风险之间关联的研究报告结果相互矛盾。因此，进行了一项荟萃分析以总结有关潜在关联的数据。
检索了Pubmed、Embase和CBM数据库中的所有可用研究。通过比值比（OR）及其95%置信区间（CI）评估TSER 2R/3R多态性与CRC风险之间的联系。
本荟萃分析纳入了7项病例对照研究，共2723例病例和4030例对照。结果显示，在两种比较模型中，TSER 2R/3R多态性的3R变体与CRC风险相关（OR 3R vs. 2R =1.10，95%CI 1.02-1.18，P = 0.015；OR纯合子比较模型 = 1.22，95%CI 1.04-1.43，P = 0.012）。按种族进行的亚组分析进一步表明，在白种人的三种比较模型中存在关联（OR 3R vs. 2R = 1.10，95%CI 1.02-1.19，P = 0.015；OR纯合子比较模型 = 1.21，95%CI 1.03-1.41，P = 0.019；OR隐性比较模型 = 1.18，95%CI 1.05-1.通过比值比（OR）及其95%置信区间（CI）评估TSER 2R/3R多态性与CRC风险之间的联系。
本荟萃分析纳入了7项病例对照研究，共2723例病例和4030例对照。结果显示，在两种比较模型中，TSER 2R/3R多态性的3R变体与CRC风险相关（OR 3R vs. 2R =1.10，95%CI 1.02-1.18，P = 0.015；OR纯合子比较模型 = 1.22，95%CI 1.04-1.43，P = 0.012）。按种族进行的亚组分析进一步表明，在白种人的三种比较模型中存在关联（OR 3R vs. 2R = 1.10，95%CI 1.02-1.19，P = 0.015；OR纯合子比较模型 = 1.21，95%CI 1.03-1.41，P = 0.019；OR隐性比较模型 = 1.18，95%CI 1.05-1.33，P = 0.008）。然而，由于数据有限，亚洲人群中的关联仍不确定（所有P值均大于0.05）。
我们的荟萃分析表明，胸苷酸合成酶5'-非翻译增强区2R/3R多态性的3R变体与白种人群体的胃癌风险相关，而亚洲人群中的任何关联都需要进一步研究。
