Qiao Zhaohua, Lou Dan, Ruan Li
Department of Pediatrics, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Medicine (Baltimore). 2017 Feb;96(7):e6143. doi: 10.1097/MD.0000000000006143.
Accumulating studies have explored the effect of thymidylate synthase enhancer region (TSER) variation on risk of pediatric acute lymphoblastic leukemia (ALL) with controversial results. Therefore, this quantitative meta-analysis was performed to assess synthetically the association of TSER variation with susceptibility to develop pediatric ALL.
The PubMed, ScienceDirect, Google Scholar, Wanfang Database, and China National Knowledge Infrastructure were systematically retrieved to obtain the published case-control studies about the relationship between TSER variation and pediatric ALL risk. The quality assessment of the included studies was preformed and relevant information was collected. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the strength of association.
This meta-analysis finally included 2681 children with ALL and 3854 matched controls from 11 investigations. The quantitative synthesis results found no significant association between TSER variation and susceptibility to pediatric ALL in overall comparisons under 5 genetic models (2R/3R vs 3R/3R: OR = 0.95, 95% CI = 0.84-1.07, P = 0.41; 2R/2R vs 3R/3R: OR = 0.99, 95% CI = 0.84-1.16, P = 0.90; 2R2R vs 3R/3R+2R/3R: OR = 1.05, 95% CI = 0.92-1.21, P = 0.45; 2R/3R+2R/2R vs 3R/3R: OR = 0.97, 95% CI = 0.87-1.09, P = 0.63; 2R vs 3R: OR = 1.03, 95% CI = 0.92-1.15, P = 0.61). Similarly, there was no significant association existed in the stratification analyses according to ethnicity, control source, and quality score.
This meta-analysis shows that TSER variation is not related to the development risk of pediatric ALL.
越来越多的研究探讨了胸苷酸合成酶增强子区域（TSER）变异对小儿急性淋巴细胞白血病（ALL）风险的影响，但结果存在争议。因此，进行了这项定量荟萃分析，以综合评估TSER变异与小儿ALL易感性之间的关联。
系统检索了PubMed、ScienceDirect、谷歌学术、万方数据库和中国知网，以获取已发表的关于TSER变异与小儿ALL风险关系的病例对照研究。对纳入研究进行质量评估并收集相关信息。应用比值比（OR）和95%置信区间（CI）评估关联强度。
该荟萃分析最终纳入了来自11项研究的2681例ALL患儿和3854例匹配对照。定量综合结果发现在5种遗传模型下的总体比较中，TSER变异与小儿ALL易感性之间无显著关联（2R/3R与3R/3R：OR = 0.95，95% CI = 0.84 - 1.07，P = 0.41；2R/2R与3R/3R：OR = 0.99，95% CI = 0.84 - 1.16，P = 0.90；2R2R与3R/3R + 2R/3R：OR = 1.05，95% CI = 0.92 - 1.21，P = 0.45；2R/3R + 2R/2R与3R/3R：OR = 0.97，95% CI = 0.87 - 1.09，P = 0.63；2R与3R：OR = 1.03，95% CI = 0.92 - 1.15，P = 0.61）。同样，在按种族、对照来源和质量评分进行的分层分析中也无显著关联。
该荟萃分析表明TSER变异与小儿ALL的发病风险无关。
