谷胱甘肽S-转移酶T1基因缺失型基因型增加亚洲人患前列腺癌的风险：一项荟萃分析。
The GSTT1 null genotype contributes to increased risk of prostate cancer in Asians: a meta-analysis.
作者信息
Pan Zhao-Jun, Huang Wei-Jia, Zou Zi-Hao, Gao Xing-Cheng
机构信息
Department of Urology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
出版信息
Asian Pac J Cancer Prev. 2012;13(6):2635-8. doi: 10.7314/apjcp.2012.13.6.2635.
BACKGROUND
Many studies have investigated the association between glutathione S-transferase T 1 (GSTT1) null genotype and risk of prostate cancer, but the impact of GSTT1 null genotype in Asians is still unclear owing to inconsistencies across results. Thie present meta-analysis aimed to quantify the strength of the association between GSTT1 null genotype and risk of prostate cancer.
METHODS
We searched the PubMed, Embase and Wangfang databases for studies of associations between the GSTT1 null genotype and risk of prostate cancer in Asians and estimated summary odds ratio (OR) with their 95% confidence interval (95% CI).
RESULTS
A total of 11 case-control studies with 3,118 subjects were included in this meta-analysis, which showed the GSTT1 null genotype to be significantly associated with increased risk of prostate cancer in Asians (random-effects OR = 1.49, 95% CI 1.15-1.92, P = 0.002), also after adjustment for heterogeneity (fixed-effects OR = 1.45, 95% CI 1.23-1.70, P< 0.001). No evidence of publication bias was observed.
CONCLUSIONS
This meta-analysis of available data suggested the GSTT1 null genotype does contribute to increased risk of prostate cancer in Asians.
背景
许多研究调查了谷胱甘肽S-转移酶T1（GSTT1）缺失基因型与前列腺癌风险之间的关联，但由于结果不一致，GSTT1缺失基因型在亚洲人中的影响仍不明确。本荟萃分析旨在量化GSTT1缺失基因型与前列腺癌风险之间关联的强度。
方法
我们在PubMed、Embase和万方数据库中搜索了关于亚洲人GSTT1缺失基因型与前列腺癌风险关联的研究，并估计了汇总比值比（OR）及其95%置信区间（95%CI）。
结果
本荟萃分析共纳入11项病例对照研究，涉及3118名受试者，结果显示GSTT1缺失基因型与亚洲人前列腺癌风险增加显著相关（随机效应OR = 1.49，95%CI 1.15 - 1.92，P = 0.002），在调整异质性后也是如此（固定效应OR = 1.45，95%CI 1.23 - 1.70，P < 0.001）。未观察到发表偏倚的证据。
结论
对现有数据的这项荟萃分析表明，GSTT1缺失基因型确实会增加亚洲人患前列腺癌的风险。
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